Bjerrum Søren Solborg, la Cour Morten
Department of Ophthalmology, Rigshospitalet Glostrup, Nordre Ringvej 57, 2600, Glostrup, Copenhagen, Denmark.
Graefes Arch Clin Exp Ophthalmol. 2017 Oct;255(10):2023-2027. doi: 10.1007/s00417-017-3760-4. Epub 2017 Aug 8.
To study the epidemiology of patients with endogenous endophthalmitis in Denmark.
Retrospective and prospective case series of 59 eyes in patients with endogenous endophthalmitis in Denmark between 2000 and 2016.
The age of the patients ranged from 28 to 90 years with a median of 66 years. Sixty-two percent of the eyes had a final VA (visual acuity) ≤ 0.1 while 8% had a final VA ≥ 1.0. Positive cultures were obtained in 51% of the cases from the blood and in 43% from the vitreous. Streptococcus species and Staphylococcus aureus were the most commonly identified microorganisms. The sources of endogenous endophthalmitis were diverse and were not identified in 36% of the patients. Diabetes (36%) was the most predisposing medical illness. A total of 15% of the patients died within the first year after surgery for endophthalmitis and half of the patients died during follow up. The mortality of patients was 22.6 times higher compared to a Danish background population. Culture positive patients had a higher mortality compared to culture negative patients.
Endogenous endophthalmitis is a heterogeneous condition which is reflected in the age, the visual outcome and the mortality of the patients. The epidemiology of the disease is very different in Scandinavia compared to Asia. The visual prognosis remains grave and the majority of the eyes lose useful vision.
研究丹麦内源性眼内炎患者的流行病学情况。
对2000年至2016年间丹麦59例内源性眼内炎患者的59只眼进行回顾性和前瞻性病例系列研究。
患者年龄范围为28至90岁，中位数为66岁。62%的患眼最终视力（VA）≤0.1，而8%的患眼最终视力≥1.0。51%的病例血培养呈阳性，43%的病例玻璃体培养呈阳性。链球菌属和金黄色葡萄球菌是最常鉴定出的微生物。内源性眼内炎的感染源多种多样，36%的患者感染源未明确。糖尿病（36%）是最主要的易感疾病。共有15%的患者在眼内炎手术后第一年内死亡，半数患者在随访期间死亡。与丹麦普通人群相比，患者的死亡率高出22.6倍。培养阳性患者的死亡率高于培养阴性患者。
内源性眼内炎是一种异质性疾病，这体现在患者的年龄、视力预后和死亡率上。与亚洲相比，斯堪的纳维亚半岛这种疾病的流行病学情况差异很大。视力预后仍然很严峻，大多数患眼失去有用视力。
