Clinical Laboratory Department, First People's Hospital of Linping District, Hangzhou, Hangzhou, Zhejiang Province, People's Republic of China.
Clinical Laboratory Department, The People's Hospital of Cangnan Zhejiang, Wenzhou, Zhejiang Province, People's Republic of China.
Sci Rep. 2024 Jul 9;14(1):15806. doi: 10.1038/s41598-024-66929-7.
To evaluate the clinical significance of PLT, MPV, and PDW in monitoring malaria treatment efficacy and predicting disease progression. A total of 31 patients with imported malaria were selected as the observation group, while 31 non-malaria patients with fever were selected as controls. The observation group was subdivided into a complication group and a non-complication group according to the occurrence of complications during treatment. Additionally, on the 1st day (within 24 h), the 3rd day, and the 5th day following admission, a comprehensive blood routine examination, Plasmodium microscopic examination, and colloidal gold assay were conducted. The blood routine examination results were compared before and after treatment among patients in the observation group and the control group. Moreover, the study involved dynamic monitoring and analysis of the levels and variations in PLT, MPV, and PDW within both the complication group and the non-complication group. The Plasmodium density was negatively correlated with PLT before treatment. There were significant differences were observed in PLT, MPV, and PDW (P < 0.05) within the observation group before and after treatment. Notably, there were no significant alterations in red blood cell (RBC), hemoglobin (Hb), and white blood cell (WBC) counts (P > 0.05) within the observation group before and after treatment. The PLT, MPV, and PDW levels in the complication group and the non-complication group exhibited an upward trend after treatment. Further, the PLT of patients in the complication group was significantly lower than that in the non-complication group. Additionally, the PLT, MPV, and PDW levels in the complication group and the non-complication group increased gradually from the time of admission to the 3rd and 5th day of treatment. Notably, the PLT in the complication group was consistently lower than that in the non-complication group. The continuous monitoring of PLT, MPV, and PDW changes plays a crucial role in assessing malaria treatment efficacy and prognosis in these individuals.
为了评估 PLT、MPV 和 PDW 在监测疟疾治疗效果和预测疾病进展方面的临床意义。选择 31 例输入性疟疾患者为观察组，选择 31 例发热非疟疾患者为对照组。根据治疗过程中是否发生并发症，观察组分为并发症组和非并发症组。此外，在入院第 1 天（24 小时内）、第 3 天和第 5 天进行全面血常规检查、疟原虫镜检和胶体金检测。比较观察组和对照组患者治疗前后的血常规检查结果。同时，对并发症组和非并发症组患者的 PLT、MPV 和 PDW 水平及变化进行动态监测和分析。治疗前疟原虫密度与 PLT 呈负相关。观察组治疗前后 PLT、MPV 和 PDW 差异有统计学意义（P<0.05）。观察组治疗前后红细胞（RBC）、血红蛋白（Hb）和白细胞（WBC）计数差异无统计学意义（P>0.05）。并发症组和非并发症组患者治疗后 PLT、MPV 和 PDW 水平呈上升趋势，且并发症组患者 PLT 明显低于非并发症组。此外，并发症组和非并发症组患者从入院到治疗第 3 天和第 5 天，PLT、MPV 和 PDW 水平逐渐升高，且并发症组 PLT 一直低于非并发症组。连续监测 PLT、MPV 和 PDW 的变化，对评估疟疾患者的治疗效果和预后具有重要意义。
