DiVito Kyle A, Daniele Michael A, Roberts Steven A, Ligler Frances S, Adams André A
Center for Bio/Molecular Science & Engineering US Naval Research Laboratory, 4555 Overlook Ave. SW, Washington D.C. 20375, United States.
Department of Electrical & Computer Engineering North Carolina State University, 890 Oval Dr., Raleigh NC 27695, United States.
Data Brief. 2017 Jul 15;14:156-162. doi: 10.1016/j.dib.2017.07.011. eCollection 2017 Oct.
This data article provides further detailed information related to our research article titled "Microfabricated Blood Vessels Undergo Neovascularization" (DiVito et al., 2017) [1], in which we report fabrication of human blood vessels using hydrodynamic focusing (HDF). Hydrodynamic focusing with advection inducing chevrons were used in concert to encase one fluid stream within another, shaping the inner core fluid into 'bullseye-like" cross-sections that were preserved through click photochemistry producing streams of cellularized hollow 3-dimensional assemblies, such as human blood vessels (Daniele et al., 2015a, 2015b, 2014, 2016; Roberts et al., 2016) [2], [3], [4], [5], [6]. Applications for fabricated blood vessels span general tissue engineering to organ-on-chip technologies, with specific utility in drug delivery and pharmacodynamics studies. Here, we report data regarding the construction of blood vessels including cellular composition and cell positioning within the engineered vascular construct as well as functional aspects of the tissues.
本数据文章提供了与我们的研究文章《微制造血管经历新生血管形成》（迪维托等人，2017年）[1]相关的进一步详细信息，在该研究文章中，我们报告了使用流体动力聚焦（HDF）制造人体血管的过程。流体动力聚焦与诱导平流的人字形结构协同使用，将一股流体流包裹在另一股流体流中，将内芯流体塑造成“靶心状”横截面，通过点击光化学得以保留，从而产生细胞化的中空三维组件流，如人体血管（达尼埃莱等人，2015年a、2015年b、2014年、2016年；罗伯茨等人，2016年）[2]、[3]、[4]、[5]、[6]。制造血管的应用涵盖一般组织工程到芯片器官技术，在药物递送和药效学研究中有特定用途。在此，我们报告有关血管构建的数据，包括工程化血管构建物中的细胞组成和细胞定位以及组织的功能方面。
