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2015年9月在西班牙从牛身上分离出的多重耐药性大肠杆菌中耐黏菌素基因mcr-1和mcr-3的共现情况。

Co-occurrence of colistin-resistance genes mcr-1 and mcr-3 among multidrug-resistant Escherichia coli isolated from cattle, Spain, September 2015.

作者信息

Hernández Marta, Iglesias M Rocío, Rodríguez-Lázaro David, Gallardo Alejandro, Quijada Narciso, Miguela-Villoldo Pedro, Campos Maria Jorge, Píriz Segundo, López-Orozco Gema, de Frutos Cristina, Sáez José Luis, Ugarte-Ruiz María, Domínguez Lucas, Quesada Alberto

机构信息

Laboratorio de Biología Molecular y Microbiología, Instituto Tecnológico Agrario de Castilla y León, Valladolid, Spain.

Departamento de Ingeniería Agrícola y Forestal, Tecnología de los Alimentos, Escuela Técnica Superior de Ingenierías Agrarias, Universidad de Valladolid, Palencia, Spain.

出版信息

Euro Surveill. 2017 Aug 3;22(31). doi: 10.2807/1560-7917.ES.2017.22.31.30586.

DOI:10.2807/1560-7917.ES.2017.22.31.30586
PMID:28797328
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5553059/
Abstract

Colistin resistance genes mcr-3 and mcr-1 have been detected in an Escherichia coli isolate from cattle faeces in a Spanish slaughterhouse in 2015. The sequences of both genes hybridised to same plasmid band of ca 250 kb, although colistin resistance was non-mobilisable. The isolate was producing extended-spectrum beta-lactamases and belonged to serotype O9:H10 and sequence type ST533. Here we report an mcr-3 gene detected in Europe following earlier reports from Asia and the United States.

摘要

2015年，在西班牙一家屠宰场的一份牛粪便大肠杆菌分离株中检测到了耐黏菌素基因mcr - 3和mcr - 1。尽管黏菌素耐药性不可转移，但这两个基因的序列均与约250 kb的同一质粒条带杂交。该分离株产生超广谱β-内酰胺酶，属于O9:H10血清型和ST533序列型。继亚洲和美国早期报告之后，我们在此报告了在欧洲检测到的一个mcr - 3基因。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97fa/5553059/48e590ce087a/eurosurv-22-30586-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97fa/5553059/48e590ce087a/eurosurv-22-30586-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97fa/5553059/48e590ce087a/eurosurv-22-30586-f1.jpg

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