Badolato Mariateresa, Carullo Gabriele, Cione Erika, Aiello Francesca, Caroleo Maria Cristina
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria- Edificio Polifunzionale, 87036 Arcavacata di Rende, CS, Italy.
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria- Edificio Polifunzionale, 87036 Arcavacata di Rende, CS, Italy.
Eur J Med Chem. 2017 Dec 15;142:290-299. doi: 10.1016/j.ejmech.2017.07.064. Epub 2017 Aug 3.
Nowadays there is a folk medicine branch called apitherapy that aims to treat diseases with bee products, including honey. Honey has long been known for its medicinal and health promoting properties. It encloses numerous types of phytochemicals with high phenolic and flavonoid content, which contribute to its antioxidant and anti-inflammatory activities. Varieties and variants of polyphenols in honey showed antiproliferative property against several types of cancer. This review focuses on the latest discoveries about the key role of honey in different stages of carcinogenesis, initiation, proliferation and progression, both in vitro and in vivo, as well as on its adjuvant effect in cancer therapy. Although a possible application of honey and its active compounds as drugs against cancer is still far away from clinical practice, scientific results highlight that they could be used as immune booster for patients undergoing chemotherapy. They showed protective effects against the common exasperating and disabling side effects, mostly mucositis.
如今，有一个名为蜂疗的民间医学分支，旨在用蜂产品（包括蜂蜜）治疗疾病。蜂蜜长期以来因其药用和促进健康的特性而闻名。它含有多种具有高酚类和黄酮类含量的植物化学物质，这有助于其抗氧化和抗炎活性。蜂蜜中的多酚品种和变体对几种类型的癌症具有抗增殖特性。本综述重点关注蜂蜜在致癌作用的不同阶段（起始、增殖和进展）在体外和体内的关键作用的最新发现，以及其在癌症治疗中的辅助作用。尽管蜂蜜及其活性化合物作为抗癌药物的可能应用仍远离临床实践，但科学结果表明，它们可作为化疗患者的免疫增强剂。它们对常见的令人恼怒和致残的副作用（主要是粘膜炎）具有保护作用。
