Department of Food Science and Technology, Federal University of Santa Catarina, Itacorubi, Florianópolis, SC 88034-001, Brazil.
Department of Food Science and Technology, Federal University of Santa Catarina, Itacorubi, Florianópolis, SC 88034-001, Brazil.
Food Res Int. 2020 Mar;129:108756. doi: 10.1016/j.foodres.2019.108756. Epub 2019 Nov 27.
The objective of this study was to investigate and quantify the composition phenolic, reducing capacity, the free radical scavenging activity, as well as, the anti-inflammatory effect evaluated against lipopolysaccharides-stimulated RAW264.7 macrophages through modulation of inflammatory mediators, in eight stingless bee honey types (Meliponinae) from southern Brazil. Stingless bee honey did not show to be cytotoxic at the tested concentrations (1-100 µM) and also reduced nitric oxide and the secretion of the pro-inflammatory cytokine in the inflamed macrophages. Two honey samples showed the ability to increase the secretion of anti-inflammatory cytokine (interleukin-10), suggesting a significant anti-inflammatory effect. All these findings indicate that stingless bee honey could be an important source of natural compounds presenting anti-inflammatory and antioxidant effect, which could would provide health benefits when included in the diet.
本研究旨在调查和量化八种来自巴西南部的无刺蜂蜂蜜（Meliponinae）的酚类成分、还原能力、自由基清除活性以及通过调节炎症介质对脂多糖刺激的 RAW264.7 巨噬细胞的抗炎作用。无刺蜂蜂蜜在测试浓度（1-100μM）下显示出非细胞毒性，并且还降低了一氧化氮和促炎细胞因子在炎症巨噬细胞中的分泌。两种蜂蜜样品显示出增加抗炎细胞因子（白细胞介素 10）分泌的能力，表明具有显著的抗炎作用。所有这些发现表明，无刺蜂蜂蜜可能是具有抗炎和抗氧化作用的天然化合物的重要来源，当包含在饮食中时，可能会带来健康益处。
