Sharma Salil
Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, United States.
Dev Comp Immunol. 2017 Dec;77:150-156. doi: 10.1016/j.dci.2017.08.001. Epub 2017 Aug 9.
Majority of microRNAs are evolutionarily conserved in vertebrates. This is suggestive of their similar roles in regulation of gene networks. In addition to their conserved mature sequences and regulatory roles, a few microRNAs show very cell or tissue specific expression. These microRNAs are highly enriched in some cell types or organs. One such microRNA is microRNA-142 (miR-142). The classical stem-loop structure of miR142 encodes for two species of mature microRNAs; miR142-5p and miR142-3p. MiR-142 is abundant in cells of hematopoietic origin, and therefore, aptly plays a role in lineage differentiation of hematopoietic cells. Interestingly, over the years, miR-142 has gained considerable attention for its quintessential role in regulating immune response. This mini-review discusses the important functional roles of miR-142 in inflammatory and immune response in different physiological and disease setting.
大多数微小RNA在脊椎动物中具有进化保守性。这表明它们在基因网络调控中发挥着相似的作用。除了其保守的成熟序列和调控作用外，一些微小RNA表现出非常细胞或组织特异性的表达。这些微小RNA在某些细胞类型或器官中高度富集。其中一种微小RNA是微小RNA - 142（miR - 142）。miR142的经典茎环结构编码两种成熟的微小RNA；miR142 - 5p和miR142 - 3p。MiR - 142在造血起源的细胞中丰富，因此，在造血细胞的谱系分化中恰当地发挥作用。有趣的是，多年来，miR - 142因其在调节免疫反应中的关键作用而受到了相当多的关注。这篇小型综述讨论了miR - 142在不同生理和疾病背景下的炎症和免疫反应中的重要功能作用。
