From Department of Vascular Surgery, University of Helsinki and Helsinki University Hospital, Finland (M.T.L., S.J.L., P.S.A., I.K., A.A., M.V.); Center for Research Methods, Department of Social Research, University of Helsinki, Finland (R.S.); and Institute of Clinical Medicine, University of Eastern Finland, Kuopio (R.S.).
Circulation. 2017 Oct 31;136(18):1726-1734. doi: 10.1161/CIRCULATIONAHA.117.028259. Epub 2017 Aug 11.
In the event of rupture of an abdominal aortic aneurysm (AAA), mortality is very high. AAA prevalence and incidence of ruptures have been reported to be decreasing. The treatment of AAA has also undergone a change in recent decades with a shift toward endovascular aneurysm repair (EVAR). Our aim was to evaluate how these changes have affected the elective and emergency treatment of AAA and their results in Finland.
All patients treated for AAA in Finland, a country with a population of 5.5 million, during 2000 to 2014 were searched from the registry of the Finnish Institute for Health and Welfare. Data on all patients who had died of AAA during the same time period were obtained from Statistics Finland. The data were combined and analyzed.
The annual incidence of ruptured AAA was 16.4 per 100 000 population over 50 years and decreased significantly during the study period. Over half of the 4949 patients who had a ruptured AAA died outside the hospital. Thirty-day mortality after emergency repair was 39.4%. Intact AAA repairs numbered 4956. The absolute number of annual repairs increased during the study period, and the use of EVAR became the dominant method of elective repair. Thirty-day mortality in elective AAA repair dropped significantly from 6.3% in 2000 to 2004 to 2.7% in 2010 to 2014 mostly because of the increased number of EVAR procedures with lower mortality. Long-term mortality in patients treated with EVAR was higher than in patients treated with open repair. Mortality after elective AAA repair was primarily attributable to cardiovascular causes, but there was a slightly higher proportion of AAA-related late deaths in patients treated with EVAR.
Ruptured AAA incidence for men >65 years has declined by nearly 30% in Finland, likely because of the decrease in AAA prevalence. The treatment results have improved as well for both elective and emergency repair. Increased use of EVAR has resulted in a decrease of mortality after elective AAA repair, but results of open repair have improved as well. However, late mortality from elective EVAR is surprisingly high in comparison with open repair, which may have been exaggerated by patient selection.
在腹主动脉瘤(AAA)破裂的情况下,死亡率非常高。AAA 的患病率和破裂发生率据报道呈下降趋势。近年来,AAA 的治疗也发生了变化,向血管内修复(EVAR)转变。我们的目的是评估这些变化如何影响芬兰的 AAA 的择期和急诊治疗及其结果。
从芬兰卫生和福利研究所的登记处搜索了 2000 年至 2014 年期间在芬兰接受 AAA 治疗的所有患者。从芬兰统计局获得了同期死于 AAA 的所有患者的数据。对数据进行了合并和分析。
破裂性 AAA 的年发病率为每 10 万 50 岁以上人群 16.4 例,研究期间显著下降。4949 例破裂性 AAA 患者中有一半以上在医院外死亡。急诊修复后 30 天死亡率为 39.4%。完整的 AAA 修复数量为 4956 例。研究期间,每年修复的绝对数量增加,EVAR 的应用成为择期修复的主要方法。择期 AAA 修复的 30 天死亡率从 2000 年至 2004 年的 6.3%显著下降到 2010 年至 2014 年的 2.7%,主要是因为 EVAR 程序的死亡率较低,数量增加。接受 EVAR 治疗的患者的长期死亡率高于接受开放修复的患者。接受择期 AAA 修复的患者的死亡率主要归因于心血管原因,但接受 EVAR 治疗的患者中 AAA 相关晚期死亡的比例略高。
芬兰 >65 岁男性的破裂性 AAA 发病率下降了近 30%,这可能是由于 AAA 患病率的下降。择期和急诊治疗的结果也有所改善。EVAR 的使用增加导致择期 AAA 修复后的死亡率下降,但开放修复的结果也有所改善。然而,与开放修复相比,择期 EVAR 的晚期死亡率出人意料地高,这可能是由于患者选择的夸大。