Department of Applied Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University, Tsushima-Naka, Kita-ku, Okayama 700-8530, Japan.
Curr Opin Virol. 2017 Oct;26:120-124. doi: 10.1016/j.coviro.2017.07.023. Epub 2017 Aug 12.
Various RNA/DNA viruses have caused severe infectious diseases in plants as well as animals, including humans, and been a threat to the production of agricultural crops. Therefore, prevention of plant virus infections is a major objective in crop protection. One attractive approach is to inhibit functions of viral proteins responsible for virus infections. In this review, I describe the status using such approaches to confer virus resistance to plants by three types of peptides/proteins: peptide aptamers, artificial zinc finger proteins and acidic peptides. These approaches vary in their specificity, broadness to other viruses, extent of protection and mechanisms of action. Additional ways to improve these approaches are also discussed.
各种 RNA/DNA 病毒在植物以及动物（包括人类）中引起了严重的传染病，对农业作物的生产造成了威胁。因此，预防植物病毒感染是作物保护的主要目标。一种有吸引力的方法是抑制负责病毒感染的病毒蛋白的功能。在这篇综述中，我描述了使用三种类型的肽/蛋白：肽适体、人工锌指蛋白和酸性肽，通过三种方法使植物具有抗病毒特性的研究现状：肽适体、人工锌指蛋白和酸性肽。这些方法在特异性、对其他病毒的广谱性、保护程度和作用机制上有所不同。还讨论了改进这些方法的其他方法。
