Ziadi Asraa, Uchida Naoyuki, Kato Hiroe, Hisamatsu Rina, Sato Ayato, Hagihara Shinya, Itami Kenichiro, Torii Keiko U
Institute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University, Chikusa, Nagoya, 464-8601, Japan.
Chem Commun (Camb). 2017 Aug 24;53(69):9632-9635. doi: 10.1039/c7cc04526c.
The increasing climate changes and global warming are leading to colossal agricultural problems such as abatement of food production and quality. As stomatal development is considered to play a key role in crop plant productivity and water-use efficiency, studying stomatal development is useful for understanding the productivity of plant systems for both natural and agricultural systems. Herein, we report the first-in-class synthetic small molecules enhancing the number of stomata in Arabidopsis thaliana that have been discovered by screening of the chemical library and further optimized by the Pd-catalyzed C-H arylation reaction. The present study shows not only huge potential of small molecules to control the cellular and developmental processes of stomata without using genetically modified plants, but also the power of C-H functionalization chemistry to rapidly identify the optimized compounds.
日益加剧的气候变化和全球变暖正导致巨大的农业问题，如粮食产量和质量的下降。由于气孔发育被认为在作物生产力和水分利用效率方面起着关键作用，研究气孔发育有助于理解自然和农业系统中植物系统的生产力。在此，我们报告了通过化学文库筛选发现并经钯催化的C-H芳基化反应进一步优化的、在拟南芥中增加气孔数量的一流合成小分子。本研究不仅显示了小分子在不使用转基因植物的情况下控制气孔细胞和发育过程的巨大潜力，还展示了C-H官能团化化学在快速鉴定优化化合物方面的作用。
