揭示由p19Arf和干扰素-β基因转移至癌细胞引发的免疫治疗循环：一种免疫原性细胞死亡诱导剂。
Uncovering the immunotherapeutic cycle initiated by p19Arf and interferon-β gene transfer to cancer cells: An inducer of immunogenic cell death.
作者信息
Medrano Ruan F V, Hunger Aline, Catani João P P, Strauss Bryan E
机构信息
Viral Vector Laboratory, Center for Translational Investigation in Oncology, Cancer Institute of Sao Paulo/LIM 24, University of Sao Paulo School of Medicine, Sao Paulo, Brazil.
出版信息
Oncoimmunology. 2017 May 19;6(7):e1329072. doi: 10.1080/2162402X.2017.1329072. eCollection 2017.
Abstract
Simultaneous reestablishment of p53/p19 and interferon-β pathways in melanoma cells culminates in a cell death process that displays features of necroptosis along with the release of immunogenic cell death molecules and unleashes an antitumor immune response mediated by natural killer cells, neutrophils as well as CD4 and CD8 T lymphocytes.
摘要
黑色素瘤细胞中p53/p19和干扰素-β信号通路的同时重建最终导致细胞死亡过程，该过程表现出坏死性凋亡的特征，同时释放免疫原性细胞死亡分子，并引发由自然杀伤细胞、中性粒细胞以及CD4和CD8 T淋巴细胞介导的抗肿瘤免疫反应。
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本文引用的文献
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Reestablishment of p53/Arf and interferon- pathways mediated by a novel adenoviral vector potentiates antiviral response and immunogenic cell death.一种新型腺病毒载体介导的p53/Arf和干扰素通路的重建增强了抗病毒反应和免疫原性细胞死亡。
Cell Death Discov. 2017 Mar 20;3:17017. doi: 10.1038/cddiscovery.2017.17. eCollection 2017.
2
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