Michna H
Virchows Arch B Cell Pathol Incl Mol Pathol. 1986;52(1):75-86. doi: 10.1007/BF02889952.
The organisation of tendon collagen fibrils has been studied by electron microscopy after treatment with an anabolic steroid hormone in a short-term and a long-term study. The effect of anabolic steroids is of interest because of their use in competitive sports and in clinical therapy. In a functional experimental model the unexpected occurrence of dysplastic as well as ruptured and dissociated collagen fibrils was revealed. The striking time-dependent collagen dysplasia and other pathological findings strongly suggest that in mice anabolic steroid treatment predisposes to tendon rupture especially when the animals are exercised. The possible underlying mode of action of anabolic steroid hormone on connective tissue is discussed.
在一项短期和一项长期研究中，通过电子显微镜观察了合成代谢类固醇激素处理后肌腱胶原纤维的组织情况。合成代谢类固醇的作用备受关注，因为它们被用于竞技体育和临床治疗。在一个功能性实验模型中，发现了发育异常以及破裂和解离的胶原纤维的意外出现。显著的时间依赖性胶原发育异常和其他病理发现强烈表明，在小鼠中，合成代谢类固醇治疗易导致肌腱断裂，尤其是在动物运动时。讨论了合成代谢类固醇激素对结缔组织可能的潜在作用方式。
