Svanberg Emilie Krite, Lundin Patrik, Larsson Marcus, Åkeson Jonas, Svanberg Katarina, Svanberg Sune, Andersson-Engels Stefan, Fellman Vineta
Department of Clinical Sciences, Anesthesiology and Intensive Care Medicine, Skåne University Hospital, Lund University, Malmö, Sweden.
Department of Physics, Lund University, Lund, Sweden.
Pediatr Res. 2016 Apr;79(4):621-8. doi: 10.1038/pr.2015.267. Epub 2015 Dec 17.
Newborn infants may have pulmonary disorders with abnormal gas distribution, e.g., respiratory distress syndrome. Pulmonary radiography is the clinical routine for diagnosis. Our aim was to investigate a novel noninvasive optical technique for rapid nonradiographic bedside detection of oxygen gas in the lungs of full-term newborn infants.
Laser spectroscopy was used to measure contents of oxygen gas (at 760 nm) and of water vapor (at 937 nm) in the lungs of 29 healthy newborn full-term infants (birth weight 2,900-3,900 g). The skin above the lungs was illuminated using two low-power diode lasers and diffusely emerging light was detected with a photodiode.
Of the total 390 lung measurements performed, clear detection of oxygen gas was recorded in 60%, defined by a signal-to-noise ratio of >3. In all the 29 infants, oxygen was detected. Probe and detector positions for optimal pulmonary gas detection were determined. There were no differences in signal quality with respect to gender, body side or body weight.
The ability to measure pulmonary oxygen content in healthy full-term neonates with this technique suggests that with further development, the method might be implemented in clinical practice for lung monitoring in neonatal intensive care.
新生儿可能患有气体分布异常的肺部疾病，例如呼吸窘迫综合征。肺部放射摄影是临床诊断的常规方法。我们的目的是研究一种新型非侵入性光学技术，用于在足月新生儿肺部快速进行非放射摄影的床边氧气检测。
使用激光光谱法测量29名健康足月新生儿（出生体重2900 - 3900克）肺部的氧气含量（760纳米处）和水蒸气含量（937纳米处）。使用两个低功率二极管激光器照射肺部上方的皮肤，并用光电二极管检测漫射出来的光。
在总共进行的390次肺部测量中，60%记录到了清晰的氧气检测结果，定义为信噪比>3。在所有29名婴儿中均检测到了氧气。确定了用于最佳肺部气体检测的探头和探测器位置。在性别、身体侧别或体重方面，信号质量没有差异。
用该技术测量健康足月新生儿肺部氧气含量的能力表明，随着进一步发展，该方法可能会在临床实践中用于新生儿重症监护中的肺部监测。
