Malenka R C, Ayoub G S, Nicoll R A
Brain Res. 1987 Feb 10;403(1):198-203. doi: 10.1016/0006-8993(87)90145-4.
Phorbol esters enhance synaptic transmission in the rat hippocampal slice preparation most likely by acting at a presynaptic locus. To more directly examine the actions of phorbol esters on neurotransmitter release we have measured their effects on the occurrence of spontaneous postsynaptic potentials as well as on the potassium stimulated release of endogenous glutamate. Both measures of transmitter release were increased by phorbol esters suggesting a functional or regulatory role for protein kinase C in controlling the release of neurotransmitter in the mammalian CNS.
佛波酯最有可能通过作用于突触前位点来增强大鼠海马脑片制备中的突触传递。为了更直接地研究佛波酯对神经递质释放的作用，我们测量了它们对自发突触后电位的发生以及对内源性谷氨酸钾刺激释放的影响。佛波酯增加了这两种神经递质释放的测量指标，表明蛋白激酶C在控制哺乳动物中枢神经系统中神经递质释放方面具有功能或调节作用。
