Saxena Shikha, Sankhla Bharat, Sundaragiri Krishna Sireesha, Bhargava Akshay
Department of Oral Pathology, Government Dental College and Hospital, Jaipur, India.
Adv Biomed Res. 2017 Jul 28;6:90. doi: 10.4103/2277-9175.211801. eCollection 2017.
The oral squamous cell carcinoma (OSCC) is one of the most common epithelial malignancies with significant morbidity and mortality. Recent observations indicate that the clinical and histological appearance of oral mucosa may not truly depict the damage occurring at the genetic level. This phenotypic and genotypic disparity may account in part for the failure to establish effective screening and surveillance protocols, based on the traditional clinical and microscopic examination. The tumor markers are playing an increasingly important role in cancer detection and management. These laboratory-based tests are potentially useful in screening for early malignancy, aiding in cancer diagnosis, determining prognosis, surveillance following curative surgery for cancer, up-front predicting drug response or resistance, and monitoring therapy in advanced disease. A systematic review of the literature was performed based on the English titles listed in the PubMed, EBSCO, Cochrane, Science Direct, ISI web Science, and SciELO databases using the keywords. Abstracts and full-text articles were assessed. This article may help to identify the potential biomarkers for screening and the molecular pathology analysis in the high-risk patients with the OSCC.
口腔鳞状细胞癌（OSCC）是最常见的上皮性恶性肿瘤之一，具有较高的发病率和死亡率。最近的观察表明，口腔黏膜的临床和组织学表现可能无法真实反映基因水平上发生的损伤。这种表型和基因型的差异可能部分解释了基于传统临床和显微镜检查未能建立有效筛查和监测方案的原因。肿瘤标志物在癌症检测和管理中发挥着越来越重要的作用。这些基于实验室的检测在筛查早期恶性肿瘤、辅助癌症诊断、确定预后、癌症根治性手术后的监测、预先预测药物反应或耐药性以及监测晚期疾病的治疗方面具有潜在用途。使用关键词，基于PubMed、EBSCO、Cochrane、Science Direct、ISI网络科学和SciELO数据库中列出的英文标题进行了文献系统综述。对摘要和全文文章进行了评估。本文可能有助于识别OSCC高危患者筛查的潜在生物标志物和分子病理学分析。
