Department of Pathology, Nowon Eulji Medical Center, Eulji University, Seoul, Republic of Korea.
Dis Markers. 2017;2017:1397063. doi: 10.1155/2017/1397063. Epub 2017 Jul 31.
Mammalian target of rapamycin (mTOR) is a key controller of cell growth and proliferation in normal tissues and solid tumors. In the present study, an immunohistochemical analysis of the expression pattern of phosphorylated mTOR (p-mTOR) was performed in human normal fetal and adult tissues and various carcinoma tissues. p-mTOR expression showed tissue and cell type specificity in normal and cancer tissues. In normal fetal and adult tissues, p-mTOR staining was observed in the intestinal crypt, intrahepatic bile ductule, pancreatic duct, distal nephron of the kidney, umbrella cell of urothelium, mesothelial cell, and choroid plexus. In cancer tissues, p-mTOR expression was higher in adenocarcinoma than in other types of cancers, in metastatic cancer than in primary cancer, and in the forefront of the infiltrating cancer cells. These results suggest that p-mTOR is implicated not only in cell proliferation but also in tubular morphogenesis in normal and cancer tissues. In addition, mTOR activation appears to be associated with cancer cell invasion and migration in solid tumors.
哺乳动物雷帕霉素靶蛋白（mTOR）是正常组织和实体肿瘤中细胞生长和增殖的关键控制器。在本研究中，对人正常胎儿和成人组织以及各种癌组织中磷酸化 mTOR（p-mTOR）的表达模式进行了免疫组织化学分析。p-mTOR 在正常和癌组织中的表达具有组织和细胞类型特异性。在正常胎儿和成人组织中，p-mTOR 染色可见于肠隐窝、肝内胆管、胰腺导管、肾脏远端肾单位、尿路上皮伞细胞、间皮细胞和脉络丛。在癌组织中，腺癌中 p-mTOR 的表达高于其他类型的癌症，转移性癌症中 p-mTOR 的表达高于原发性癌症，并且在浸润性癌细胞的前沿。这些结果表明，p-mTOR 不仅参与细胞增殖，而且参与正常和癌组织中的管状形态发生。此外，mTOR 激活似乎与实体瘤中癌细胞的侵袭和迁移有关。
