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微小 RNA-106a 通过靶向骨转移肺癌中的 TP53INP1 调控自噬相关细胞死亡和 EMT。

MicroRNA-106a regulates autophagy-related cell death and EMT by targeting TP53INP1 in lung cancer with bone metastasis.

机构信息

Bone and Soft Tissue Tumors Research Center of Yunnan Province, Department of Orthopaedics, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Center, Kunming, Yunnan, China.

Medical School, Kunming University of Science and Technology, Kunming, Yunnan, China.

出版信息

Cell Death Dis. 2021 Oct 30;12(11):1037. doi: 10.1038/s41419-021-04324-0.

DOI:10.1038/s41419-021-04324-0
PMID:34718338
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8557209/
Abstract

Bone metastasis is one of the most serious complications in lung cancer patients. MicroRNAs (miRNAs) play important roles in tumour development, progression and metastasis. A previous study showed that miR-106a is highly expressed in the tissues of lung adenocarcinoma with bone metastasis, but its mechanism remains unclear. In this study, we showed that miR-106a expression is dramatically increased in lung cancer patients with bone metastasis (BM) by immunohistochemical analysis. MiR-106a promoted A549 and SPC-A1 cell proliferation, migration and invasion in vitro. The results of bioluminescence imaging (BLI), micro-CT and X-ray demonstrated that miR-106a promoted bone metastasis of lung adenocarcinoma in vivo. Mechanistic investigations revealed that miR-106a upregulation promoted metastasis by targeting tumour protein 53-induced nuclear protein 1 (TP53INP1)-mediated metastatic progression, including cell migration, autophagy-dependent death and epithelial-mesenchymal transition (EMT). Notably, autophagy partially attenuated the effects of miR-106a on promoting bone metastasis in lung adenocarcinoma. These findings demonstrated that restoring the expression of TP53INP1 by silencing miR-106a may be a novel therapeutic strategy for bone metastatic in lung adenocarcinoma.

摘要

骨转移是肺癌患者最严重的并发症之一。微小 RNA（miRNAs）在肿瘤的发生、发展和转移中发挥着重要作用。先前的研究表明，miR-106a 在伴有骨转移的肺腺癌组织中高表达，但具体机制尚不清楚。本研究通过免疫组织化学分析表明，miR-106a 在伴有骨转移（BM）的肺癌患者中表达显著增加。miR-106a 在体外促进 A549 和 SPC-A1 细胞的增殖、迁移和侵袭。生物发光成像（BLI）、微 CT 和 X 射线的结果表明，miR-106a 促进了肺腺癌的骨转移。机制研究表明，miR-106a 通过靶向肿瘤蛋白 53 诱导核蛋白 1（TP53INP1）介导的转移进展，包括细胞迁移、自噬依赖性死亡和上皮-间充质转化（EMT），上调促进转移。值得注意的是，自噬部分减弱了 miR-106a 对促进肺腺癌骨转移的作用。这些发现表明，通过沉默 miR-106a 恢复 TP53INP1 的表达可能是治疗肺腺癌骨转移的一种新策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48ff/8557209/5eb7be91b50c/41419_2021_4324_Fig7_HTML.jpg
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本文引用的文献

1
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2
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Transl Lung Cancer Res. 2021 Jan;10(1):439-451. doi: 10.21037/tlcr-20-835.
3
Integrative p53, micro-RNA and Cathepsin Protease Co-Regulatory Expression Networks in Cancer.癌症中整合的p53、微小RNA和组织蛋白酶蛋白酶共调控表达网络
靶向自噬相关非编码RNA在肺癌治疗中的潜力。
Front Pharmacol. 2025 May 14;16:1551258. doi: 10.3389/fphar.2025.1551258. eCollection 2025.
4
miRNA changes associated with differentiation of human embryonic stem cells into human retinal ganglion cells.与人类胚胎干细胞分化为人类视网膜神经节细胞相关的微小RNA变化
Sci Rep. 2024 Dec 30;14(1):31895. doi: 10.1038/s41598-024-83381-9.
5
A Multi-Task Model for Pulmonary Nodule Segmentation and Classification.一种用于肺结节分割与分类的多任务模型。
J Imaging. 2024 Sep 20;10(9):234. doi: 10.3390/jimaging10090234.
6
Epigenetic Modifiers in Cancer Metastasis.癌症转移中的表观遗传修饰物。
Biomolecules. 2024 Jul 27;14(8):916. doi: 10.3390/biom14080916.
7
Identification and validation of miRNA-target genes network in pediatric brain tumors.儿童脑肿瘤中 miRNA 靶基因网络的鉴定和验证。
Sci Rep. 2024 Aug 2;14(1):17922. doi: 10.1038/s41598-024-68945-z.
8
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9
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Cancers (Basel). 2020 Nov 20;12(11):3454. doi: 10.3390/cancers12113454.
4
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5
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6
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7
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10
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