患腹泻新生犊牛的血脂变化
Alterations in lipid profile in neonatal calves affected by diarrhea.
作者信息
Bozukluhan K, Merhan O, Gokce H I, Deveci H A, Gokce G, Ogun M, Marasli S
机构信息
Kars School of Higher Vocational Education, University of Kafkas, Kars, Turkey.
Department of Biochemistry, Faculty of Veterinary Medicine, University of Kafkas, Kars, Turkey.
出版信息
Vet World. 2017 Jul;10(7):786-789. doi: 10.14202/vetworld.2017.786-789. Epub 2017 Jul 16.
AIM
The aim of this study was to determine the alterations in the lipid profile, plasma alkaline phosphatase (ALP) activity, total and direct bilirubin levels of neonatal calves with diarrhea.
MATERIALS AND METHODS
A total of 25 calves with diarrhea as experimental group and 10 healthy calves as control group, 1-30 days old, were enrolled in the study. Blood samples were collected from jugular vein in tubes with anticoagulant agent to evaluate the concentration of triglycerides, total cholesterol, high-density lipoprotein-cholesterol (HDL-C), ALP, total and direct bilirubin. Very low-density lipoprotein-cholesterol (VLDL-C) and low-density lipoprotein-cholesterol (LDL-C) levels were calculated according to the Friedewald formula.
RESULTS
Significant increases in the plasma levels of ALP (p<0.05), total and direct bilirubin, triglycerides, and VLDL-C (p<0.01) were determined, whereas significant decreases in the levels of total cholesterol, HDL-C and LDL-C (p<0.01) were observed in neonatal calves with diarrhea.
CONCLUSION
According to the findings of this study, liver functions impaired and, therefore, lipid profile is affected negatively in neonatal calves with diarrhea.
目的
本研究旨在确定腹泻新生犊牛的血脂谱、血浆碱性磷酸酶（ALP）活性、总胆红素和直接胆红素水平的变化。
材料与方法
本研究共纳入25头腹泻犊牛作为实验组，10头健康犊牛作为对照组，年龄均为1 - 30日龄。从颈静脉采集血样，置于含有抗凝剂的试管中，以评估甘油三酯、总胆固醇、高密度脂蛋白胆固醇（HDL - C）、ALP、总胆红素和直接胆红素的浓度。极低密度脂蛋白胆固醇（VLDL - C）和低密度脂蛋白胆固醇（LDL - C）水平根据Friedewald公式计算。
结果
腹泻新生犊牛的血浆ALP水平（p<0.05）、总胆红素和直接胆红素、甘油三酯以及VLDL - C水平（p<0.01）显著升高，而总胆固醇、HDL - C和LDL - C水平（p<0.01）显著降低。
结论
根据本研究结果，腹泻新生犊牛的肝功能受损，因此血脂谱受到负面影响。
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