Institute for Complex Molecular Systems, Laboratory for Chemical Biology, and Laboratory for Cell and Tissue Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB, Eindhoven, The Netherlands.
Adv Healthc Mater. 2018 Jan;7(1). doi: 10.1002/adhm.201700505. Epub 2017 Aug 25.
Biomaterials with excellent blood-compatibility are needed for applications in vascular replacement therapies, such as vascular grafts, heart valves and stents, and in extracorporeal devices such as hemodialysis machines and blood-storage bags. The modification of materials that are being used for blood-contacting devices has advanced from passive surface modifications to the design of more complex, smart biomaterials that respond to relevant stimuli from blood to counteract coagulation. Logically, the main source of inspiration for the design of new biomaterials has been the endogenous endothelium. Endothelial regulation of hemostasis is complex and involves a delicate interplay of structural components and feedback mechanisms. Thus, challenges to develop new strategies for blood-compatible biomaterials now lie in incorporating true feedback controlled mechanisms that can regulate blood compatibility in a dynamic way. Here, supramolecular material systems are highlighted as they provide a promising platform to introduce dynamic reciprocity, due to their inherent dynamic nature.
用于血管替代疗法的生物材料（如血管移植物、心脏瓣膜和支架）和体外设备（如血液透析机和血袋）需要具有优异的血液相容性。用于血液接触设备的材料的改性已经从被动的表面改性发展到设计更复杂、对血液中的相关刺激做出反应以对抗凝血的智能生物材料。从逻辑上讲，设计新型生物材料的主要灵感来源是内皮层。内皮细胞对止血的调节非常复杂，涉及结构成分和反馈机制的精细相互作用。因此，开发新的血液相容性生物材料的策略目前在于结合真正的反馈控制机制，以动态方式调节血液相容性。在这里，超分子材料系统被突出强调，因为它们由于其固有动态性质而提供了引入动态相互作用的有前途的平台。
