Center for Inflammation, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, 100 Piedmont Ave, SE, Atlanta, GA 30303, USA.
Center for Inflammation, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, 100 Piedmont Ave, SE, Atlanta, GA 30303, USA.
Int Immunopharmacol. 2017 Oct;51:165-170. doi: 10.1016/j.intimp.2017.08.012. Epub 2017 Aug 30.
Chemokines are an extensive family of small proteins which, in conjunction with their receptors, guide the chemotactic activity of various immune cells throughout the body. CCL28, β- or CC chemokine, is involved in the host immunity at various epithelial and mucosal linings. The unique roles of CCL28 in several facets of immune responses have attracted considerable attention and may represent a promising approach to combat various infections. CCL28 displays a broad spectrum of antimicrobial activity against gram-negative and gram-positive bacteria, as well as fungi. Here, we will summarize various research findings regarding the antimicrobial activity of CCL28 and the relevant mechanisms behind it. We will explore how the structure of CCL28 is involved with this activity and how this function may have evolved. CCL28 displays strong homing capabilities for B and T cells at several mucosal and epithelial sites, and orchestrates the trafficking and functioning of lymphocytes. The chemotactic and immunomodulatory features of CCL28 through the interactions with its chemokine receptors, CCR10 and CCR3, will also be discussed in detail. Thus, in this review, we emphasize the dual properties of CCL28 and suggest its role as an anchoring point bridging the innate and adaptive immunity.
趋化因子是一类广泛存在的小蛋白家族，它们与受体结合，引导体内各种免疫细胞的趋化活性。CCL28，β-或 CC 趋化因子，参与各种上皮和黏膜衬里的宿主免疫。CCL28 在免疫反应的几个方面的独特作用引起了相当大的关注，并可能代表了对抗各种感染的有前途的方法。CCL28 对革兰氏阴性和革兰氏阳性细菌以及真菌表现出广谱的抗菌活性。在这里，我们将总结关于 CCL28 的抗菌活性及其相关机制的各种研究结果。我们将探讨 CCL28 的结构如何参与这种活性以及这种功能可能是如何进化的。CCL28 在几个黏膜和上皮部位对 B 和 T 细胞具有强烈的归巢能力，并协调淋巴细胞的迁移和功能。我们还将详细讨论 CCL28 通过与其趋化因子受体 CCR10 和 CCR3 的相互作用表现出的趋化和免疫调节特征。因此，在这篇综述中，我们强调了 CCL28 的双重特性，并提出了其作为连接先天免疫和适应性免疫的锚定点的作用。
