Flavell A J, Dyson J, Ish-Horowicz D
Nucleic Acids Res. 1987 May 26;15(10):4035-48. doi: 10.1093/nar/15.10.4035.
A novel family of dispersed repeat sequences from Drosophila melanogaster is described. Sequence analysis of two members of this family show them to contain greater than 75% GC bases. These are comprised of multiple repeats of GGX triplets interspersed occasionally with CGPy and TTPy. Southern blotting shows that these repeats are not transposable elements. Twenty four homologous recombinants have been localised by in situ hybridization to seven sites in the Drosophila genome. Polyadenylated RNAs homologous to this repeat family are expressed in a complex pattern which is developmentally regulated. We suggest that this family encodes a set of glycine-rich domains in Drosophila proteins.
描述了来自黑腹果蝇的一个新的分散重复序列家族。对该家族两个成员的序列分析表明,它们含有超过75%的GC碱基。这些序列由GGX三联体的多个重复序列组成,偶尔穿插着CGPy和TTPy。Southern印迹分析表明这些重复序列不是转座元件。通过原位杂交已将24个同源重组体定位到果蝇基因组的7个位点。与这个重复序列家族同源的聚腺苷酸化RNA以一种复杂的模式表达,且这种模式受发育调控。我们认为这个家族在果蝇蛋白质中编码一组富含甘氨酸的结构域。