Riaño-Umbarila Lidia, Rodríguez-Rodríguez Everardo R, Santibañez-López Carlos E, Güereca Leopoldo, Uribe-Romero Selene J, Gómez-Ramírez Ilse V, Cárcamo-Noriega Edson N, Possani Lourival D, Becerril Baltazar
CONACYT, Instituto de Biotecnología-Universidad Nacional Autónoma de México, Mexico.
Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, UNAM, Apartado Postal 510-3, Cuernavaca, Morelos, 62250, Mexico.
Toxicon. 2017 Nov;138:130-137. doi: 10.1016/j.toxicon.2017.08.022. Epub 2017 Aug 25.
The increment in the number of scorpion envenoming cases in Mexico is mainly associated to the rapid growth of the urban areas, and consequently, to the invasion of natural habitats of these arachnids. On the other hand, there is a great diversity of scorpion species, so it is indispensable to identify those of medical importance, which we now know are many more than the 7-8 previously reported as dangerous to humans. Because different LD values have been reported for the venom of the same species, probably due to variations in the experimental conditions used, in this work we determined the LD values for the venoms of 13 different species of scorpions using simple but systematic procedures. This information constitutes a referent on the level of toxicity of medically important scorpion species from Mexico and establishes the bases for a more comprehensive assessment of the neutralizing capacity of current and developing antivenoms.
墨西哥蝎子蜇伤病例数量的增加主要与城市地区的快速发展有关，因此也与这些蛛形纲动物自然栖息地的被侵占有关。另一方面，蝎子种类繁多，因此识别具有医学重要性的种类必不可少，我们现在知道这类蝎子的数量比之前报道的对人类有危险的7 - 8种要多得多。由于同一物种的毒液已报道有不同的半数致死量值，这可能是由于所使用的实验条件不同所致，因此在本研究中，我们采用简单但系统的方法测定了13种不同蝎子毒液的半数致死量值。这些信息构成了墨西哥具有医学重要性的蝎子种类毒性水平的参考依据，并为更全面评估现有和正在研发的抗蛇毒血清的中和能力奠定了基础。
