Hanson Corrine, Sayles Harlan, Rutten Erica E P A, Wouters E F M, MacNee William, Calverley Peter, Meza Jane L, Rennard Stephen
University of Nebraska Medical Center, School of Allied Health Professions, Medical Nutrition Education, Omaha.
University of Nebraska Medical Center, College of Public Health, Omaha.
Chronic Obstr Pulm Dis. 2014 May 6;1(1):115-124. doi: 10.15326/jcopdf.1.1.2014.0113.
: Diet is a potentially modifiable risk factor in the development and progression of many diseases, and there is evidence that diet plays a role in COPD. : Evaluate the relationship between dietary intake and clinical characteristics of COPD in a large and well-characterized population of COPD patients and controls who were part of the ECLIPSE study. Limited diet records were available from 2,167 participants at 8 time points over a 3-year period. Participants reported the amount they had consumed over the last 24 hours for 8 food categories. Intake of each food group was handled as a dichotomous variable (Yes/last 24 hours at any of the 8 follow-up points vs. No at all 8 points). These 2 groups were then compared using clinical outcome measures at the last available follow-up that included lung function, emphysema, 6-minute walk, St. George's Respiratory Questionaire (SGRQ) scores, the change in these scores over a 3-year period, and inflammatory biomarkers. Multivariate models for each food group and each outcome measure were run to adjust for confounding factors of age, sex, body mass index (BMI), and smoking. : Participants who demonstrated recent consumption of foods associated with a healthful diet, including fish, fruit, tea, and dairy products, had greater lung function measures and less decline over time, less emphysema and emphysema progression, greater 6-minute walk and SGRQ scores, and lower levels of certain inflammatory markers. Increasing the number of diet record time points that were included in the analysis improved ability to detect significant associations. : Diet as a possible modifiable risk factor in COPD continues to warrant investigation.
饮食是许多疾病发生和发展中一个潜在可改变的风险因素，并且有证据表明饮食在慢性阻塞性肺疾病（COPD）中起作用。：在参与ECLIPSE研究的大量且特征明确的COPD患者及对照人群中，评估饮食摄入量与COPD临床特征之间的关系。在三年期间的8个时间点，从2167名参与者处获得了有限的饮食记录。参与者报告了过去24小时内8类食物的摄入量。每个食物组的摄入量被作为一个二分变量处理（是/在8个随访点中的任何一个时间点过去24小时内摄入 vs. 在所有8个时间点均未摄入）。然后在最后一次可用随访时使用临床结局指标对这两组进行比较，这些指标包括肺功能、肺气肿、6分钟步行距离、圣乔治呼吸问卷（SGRQ）评分、这些评分在三年期间的变化以及炎症生物标志物。针对每个食物组和每个结局指标运行多变量模型，以调整年龄、性别、体重指数（BMI）和吸烟等混杂因素。：近期食用与健康饮食相关食物（包括鱼、水果、茶和乳制品）的参与者，肺功能指标更好且随时间下降更少，肺气肿及肺气肿进展更少，6分钟步行距离更远、SGRQ评分更高，并且某些炎症标志物水平更低。增加纳入分析的饮食记录时间点数量提高了检测显著关联的能力。：饮食作为COPD中一个可能可改变的风险因素仍值得研究。
