Li Die, Wu Xin-Xing, Gao Tingyu, Li Baoguo, Chen Shufeng
Inner Mongolia Key Laboratory of Fine Organic Synthesis, Department of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, People's Republic of China.
Org Biomol Chem. 2017 Sep 13;15(35):7282-7285. doi: 10.1039/c7ob01838j.
An efficient and concise CuCl-catalyzed C2-alkenylation reaction of benzoxazoles with allyl halides has been established. The distinctive features of this protocol include the use of an inexpensive copper salt as a catalyst, simple and readily available starting materials, and ligand-free conditions. An important application of this method to the synthesis of 1,3-diene substituted benzoxazoles has also been achieved.
已建立了一种高效且简洁的氯化铜催化苯并恶唑与卤代烯丙基的C2-烯基化反应。该方法的显著特点包括使用廉价的铜盐作为催化剂、简单且易于获得的起始原料以及无配体条件。该方法在合成1,3-二烯取代的苯并恶唑方面也取得了重要应用。
