Lujic Sanja, Simpson Judy M, Zwar Nicholas, Hosseinzadeh Hassan, Jorm Louisa
Centre for Big Data Research in Health, University of New South Wales, Sydney, Australia.
School of Public Health, University of Sydney, Sydney, Australia.
PLoS One. 2017 Aug 29;12(8):e0183817. doi: 10.1371/journal.pone.0183817. eCollection 2017.
Estimating multimorbidity (presence of two or more chronic conditions) using administrative data is becoming increasingly common. We investigated (1) the concordance of identification of chronic conditions and multimorbidity using self-report survey and administrative datasets; (2) characteristics of people with multimorbidity ascertained using different data sources; and (3) whether the same individuals are classified as multimorbid using different data sources.
Baseline survey data for 90,352 participants of the 45 and Up Study-a cohort study of residents of New South Wales, Australia, aged 45 years and over-were linked to prior two-year pharmaceutical claims and hospital admission records. Concordance of eight self-report chronic conditions (reference) with claims and hospital data were examined using sensitivity (Sn), positive predictive value (PPV), and kappa (κ).The characteristics of people classified as multimorbid were compared using logistic regression modelling.
Agreement was found to be highest for diabetes in both hospital and claims data (κ = 0.79, 0.78; Sn = 79%, 72%; PPV = 86%, 90%). The prevalence of multimorbidity was highest using self-report data (37.4%), followed by claims data (36.1%) and hospital data (19.3%). Combining all three datasets identified a total of 46 683 (52%) people with multimorbidity, with half of these identified using a single dataset only, and up to 20% identified on all three datasets. Characteristics of persons with and without multimorbidity were generally similar. However, the age gradient was more pronounced and people speaking a language other than English at home were more likely to be identified as multimorbid by administrative data.
Different individuals, with different combinations of conditions, are identified as multimorbid when different data sources are used. As such, caution should be applied when ascertaining morbidity from a single data source as the agreement between self-report and administrative data is generally poor. Future multimorbidity research exploring specific disease combinations and clusters of diseases that commonly co-occur, rather than a simple disease count, is likely to provide more useful insights into the complex care needs of individuals with multiple chronic conditions.
利用行政数据估算多种慢性病并存(存在两种或更多慢性疾病)的情况正变得越来越普遍。我们调查了:(1)使用自我报告调查和行政数据集对慢性疾病和多种慢性病并存情况进行识别的一致性;(2)使用不同数据源确定的患有多种慢性病的人群特征;以及(3)使用不同数据源时,是否会将相同个体归类为患有多种慢性病。
将澳大利亚新南威尔士州45岁及以上居民的队列研究“45岁及以上研究”中90352名参与者的基线调查数据与此前两年的药品报销记录和住院记录相链接。使用灵敏度(Sn)、阳性预测值(PPV)和kappa值(κ)来检验8种自我报告慢性疾病(参考标准)与报销及医院数据之间的一致性。使用逻辑回归模型比较被归类为患有多种慢性病的人群特征。
在医院数据和报销数据中,糖尿病的一致性最高(κ = 0.79,0.78;Sn = 79%,72%;PPV = 86%,90%)。使用自我报告数据时多种慢性病并存的患病率最高(37.4%),其次是报销数据(36.1%)和医院数据(19.3%)。综合所有三个数据集共识别出46683名(52%)患有多种慢性病的人,其中一半仅通过单一数据集识别出来,多达20%在所有三个数据集上都被识别出来。患有和未患有多种慢性病的人群特征总体相似。然而,年龄梯度更为明显,在家中说英语以外语言的人更有可能被行政数据识别为患有多种慢性病。
使用不同数据源时,被识别为患有多种慢性病的个体不同,所患疾病的组合也不同。因此,当从单一数据源确定发病率时应谨慎,因为自我报告和行政数据之间的一致性通常较差。未来关于多种慢性病并存的研究探索常见共病的特定疾病组合和疾病群,而不是简单的疾病计数,可能会为患有多种慢性疾病个体的复杂护理需求提供更有用的见解。