Mithander Amanda, Göen Thomas, Felding Gitte, Jacobsen Peter
Department of Occupational and Environmental Medicine, Copenhagen University, Bispebjerg Hospital, DK-2400 Copenhagen, NV Denmark.
Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, Friedrich-Alexander Universität Erlangen-Nürnberg, Schillerstrasse 25, D-91054 Erlangen, Germany.
J Occup Med Toxicol. 2017 Aug 25;12:26. doi: 10.1186/s12995-017-0173-6. eCollection 2017.
Preservation of museum objects with inorganic arsenic compounds and contamination of the surroundings has previously been documented. The present study addresses the exposure of museum staff by measuring arsenicals in urine. After 1 week without exposure, urinary samples were taken before and after handling of preserved skins and analysed by HPLC-ICP-MS for inorganic arsenic, arsenic metabolites and arsenobetaine. The sum of inorganic arsenic and metabolites was an index of exposure. Information about work and seafood intake was obtained by questionnaire. One out of five subjects had a work-related rise in the exposure index of 18.1 μg As/L to a post-exposure level of 37.1 μg As/L. Four subjects had no certain exposure-related increase in the index. The study indicates that museum staff may be exposed to arsenic from handling arsenic-preserved objects and supports the use of specified arsenic analysis to avoid interference from organic arsenic.
此前已有文献记载使用无机砷化合物保存博物馆藏品及其对周边环境的污染。本研究通过检测尿液中的砷化物来评估博物馆工作人员的暴露情况。在一周无暴露之后，于处理保存的兽皮前后采集尿液样本，并采用高效液相色谱 - 电感耦合等离子体质谱法分析无机砷、砷代谢物和砷甜菜碱。无机砷与代谢物的总和作为暴露指标。通过问卷调查获取工作及海鲜摄入量信息。五分之一的受试者与工作相关的暴露指标从18.1μg As/L上升至暴露后水平37.1μg As/L。四名受试者的指标无明确的与暴露相关的增加。该研究表明博物馆工作人员在处理用砷保存的物品时可能接触到砷，并支持采用特定的砷分析方法以避免有机砷的干扰。
