Siddiqui Mariam, Khan Afshin Alaf, Varan Aiden Kennedy, Esteves-Jaramillo Alejandra, Sultana Shazia, Ali Asad S, Zaidi Anita K M, Omer Saad B
Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, USA.
National Center for Child and Adolescent Health, Ministry of Health, Francisco de P. Miranda 177, Lomas de Plateros, Álvaro Obregón, 01600 Mexico City, Mexico.
Vaccine. 2017 Sep 25;35(40):5352-5359. doi: 10.1016/j.vaccine.2017.08.033. Epub 2017 Aug 30.
Maternal immunization against pertussis is a potential strategy to protect young infants from severe disease. We assessed factors associated with intention to accept pertussis vaccination among pregnant women in Karachi, Pakistan.
We conducted a cross-sectional survey between May and August 2013 in pregnant women who visited healthcare centers in urban slums of Karachi city. Women completed a survey examining socio-demographic factors, vaccination history, knowledge on pertussis disease, perception of vaccine recommendation sources, and potential influences on vaccine decision-making.
Of the 283 participants, 259 (92%) provided their intention to either accept or decline pertussis vaccination. Eighty-three percent women were willing to accept the pertussis vaccine if offered during pregnancy. About half (53%) of the participants had ever heard of pertussis disease. Perceptions of pertussis vaccine efficacy, safety, and disease susceptibility were strongly associated with intention to accept pertussis vaccine (p<0.01). Healthcare providers, Ministry of Health, and mass media were considered as highly reliable sources of vaccine recommendation and associated with intention to accept antenatal pertussis vaccination (p<0.001). Healthcare provider recommendation was a common reason cited by respondents for pregnant women to accept antenatal pertussis vaccination (p=0.0005). However, opinion of primary decision-makers in the family (husbands and in-laws) was a crucial reason cited by respondents for pregnant women to reject pertussis vaccination in pregnancy (p=0.003).
Antenatal pertussis vaccination initiatives in South Asia should strongly consider inclusion of family members, healthcare providers, national health ministries, and mass media to help implement new vaccination programs.
孕妇接种百日咳疫苗是保护幼儿免受严重疾病侵害的一项潜在策略。我们评估了巴基斯坦卡拉奇市孕妇接受百日咳疫苗接种意愿的相关因素。
2013年5月至8月，我们对到访卡拉奇市城市贫民窟医疗保健中心的孕妇进行了一项横断面调查。女性完成了一项调查，内容包括社会人口学因素、疫苗接种史、对百日咳疾病的了解、对疫苗推荐来源的认知以及对疫苗决策的潜在影响。
在283名参与者中，259名（92%）表明了接受或拒绝百日咳疫苗接种的意愿。如果在孕期提供百日咳疫苗，83%的女性愿意接种。约一半（53%）的参与者听说过百日咳疾病。对百日咳疫苗效力、安全性和疾病易感性的认知与接受百日咳疫苗的意愿密切相关（p<0.01）。医疗保健提供者、卫生部和大众媒体被视为高度可靠的疫苗推荐来源，且与接受产前百日咳疫苗接种的意愿相关（p<0.001）。医疗保健提供者的推荐是受访者提到的孕妇接受产前百日咳疫苗接种的常见原因（p=0.0005）。然而，受访者提到，家庭主要决策者（丈夫和姻亲）的意见是孕妇拒绝孕期接种百日咳疫苗的关键原因（p=0.003）。
南亚的产前百日咳疫苗接种倡议应大力考虑将家庭成员、医疗保健提供者、国家卫生部和大众媒体纳入进来，以帮助实施新的疫苗接种计划。
