Department of Food Science & Technology, University of California, Davis, USA.
Department of Anatomy, Physiology & Cell Biology, School of Veterinary Medicine, University of California, Davis, USA.
Curr Opin Biotechnol. 2018 Feb;49:140-147. doi: 10.1016/j.copbio.2017.08.004. Epub 2017 Sep 1.
Metagenomics and related methods have led to significant advances in our understanding of the human microbiome. Members of the genus Lactobacillus, although best understood for essential roles in food fermentations and applications as probiotics, have also come to the fore in a number of untargeted gut microbiome studies in humans and animals. Even though Lactobacillus is only a minor member of the human colonic microbiota, the proportions of those bacteria are frequently either positively or negatively correlated with human disease and chronic conditions. Recent findings on Lactobacillus species in human and animal microbiome research, together with the increased knowledge on probiotic and other ingested lactobacilli, have resulted in new perspectives on the importance of this genus to human health.
宏基因组学及相关方法使我们对人类微生物组有了更深入的了解。乳杆菌属的成员，虽然最被人们熟知的是在食品发酵和益生菌应用中发挥的重要作用，但在人类和动物的许多非靶向肠道微生物组研究中也崭露头角。尽管乳杆菌属只是人类结肠微生物群的一个次要成员，但这些细菌的比例经常与人类疾病和慢性疾病呈正相关或负相关。最近在人类和动物微生物组研究中对乳杆菌属的研究结果，以及对益生菌和其他摄入乳杆菌的了解的增加，使人们对该属对人类健康的重要性有了新的认识。
