哮喘与牙周病的关系：系统评价和荟萃分析。
Association between asthma and periodontal disease: A systematic review and meta-analysis.
机构信息
Department of Periodontology, School of Dentistry, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil.
Department of Orthodontics, School of Dentistry, Fluminense Federal University.
出版信息
J Periodontol. 2018 Apr;89(4):440-455. doi: 10.1902/jop.2017.170363.
BACKGROUND
The aim of this systematic review (SR) is to evaluate the association between asthma and periodontal disease.
METHODS
An electronic search without date or language restrictions was carried out in PubMed/MEDLINE, Cochrane Central Register of Controlled Trials, Web of Science, and LILACS until May 2016. In addition, manual searches and searches of the gray literature were conducted. The search process, data analysis, and quality assessment were performed by two independent reviewing authors. Eligibility criteria included prospective and retrospective cohort studies, case-controls, and randomized clinical trials.
RESULTS
The search and selection process yielded 21 studies, published between 1979 and 2017. The meta-analysis showed a statistically significant difference for the parameters of gingival bleeding, plaque index, and gingival index for participants with asthma (P < 0.001).
CONCLUSION
Data from this SR strongly suggest the association of asthma with periodontal disease.
背景
本系统评价（SR）旨在评估哮喘与牙周病之间的关联。
方法
我们在 PubMed/MEDLINE、Cochrane 对照试验中心注册库、Web of Science 和 LILACS 中进行了无日期和语言限制的电子检索，检索时间截至 2016 年 5 月。此外，还进行了手动搜索和灰色文献搜索。搜索过程、数据分析和质量评估由两位独立的评审作者进行。纳入标准包括前瞻性和回顾性队列研究、病例对照研究和随机临床试验。
结果
搜索和选择过程共产生了 21 项研究，发表时间为 1979 年至 2017 年。荟萃分析显示，哮喘患者的牙龈出血、菌斑指数和牙龈指数等参数存在统计学显著差异（P<0.001）。
结论
本 SR 的数据强烈提示哮喘与牙周病之间存在关联。
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