Department of Prosthodontics, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou, Guangdong 510182, P.R. China.
Department of Endodontics, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou, Guangdong 510182, P.R. China.
Mol Med Rep. 2024 Mar;29(3). doi: 10.3892/mmr.2024.13166. Epub 2024 Jan 19.
Periodontitis is a common chronic inflammatory and destructive disease in the mouth and is considered to be associated with systemic diseases. Accumulating evidence has suggested that periodontitis is a risk factor for pulmonary diseases such as pneumonia, chronic obstructive pulmonary disease (COPD), asthma, coronavirus disease 2019 (COVID‑19) and lung cancer. The presence of common periodontal pathogens has been detected in samples from a variety of pulmonary diseases. Periodontal pathogens can be involved in lung diseases by promoting the adhesion and invasion of respiratory pathogens, regulating the apoptosis of respiratory epithelium and inducing overexpression of mucin and disrupting the balance of immune systemin respiratory epithelium cells. Additionally, measures to control plaque and maintain the health of periodontal tissue can decrease the incidence of respiratory adverse events. This evidence suggests a close association between periodontitis and pulmonary diseases. The present study aimed to review the clinical association between periodontitis and pneumonia, COPD, asthma, COVID‑19 and lung cancer, and propose a possible mechanism and potential role of periodontal pathogens in linking periodontal disease and lung disease. This could provide a direction for further research on the association between periodontitis and lung disease and provide novel ideas for the clinical diagnosis and treatment management of these two diseases.
牙周炎是一种常见的口腔慢性炎症性破坏性疾病，被认为与全身疾病有关。越来越多的证据表明，牙周炎是肺炎、慢性阻塞性肺疾病（COPD）、哮喘、2019 冠状病毒病（COVID-19）和肺癌等肺部疾病的危险因素。在各种肺部疾病的样本中都检测到了常见的牙周病原体。牙周病原体可以通过促进呼吸道病原体的黏附和侵袭、调节呼吸道上皮细胞的凋亡、诱导粘蛋白过度表达以及破坏呼吸道上皮细胞中免疫系统的平衡，从而参与肺部疾病的发生。此外，控制菌斑和维持牙周组织健康的措施可以降低呼吸道不良事件的发生率。这些证据表明牙周炎和肺部疾病之间存在密切的关联。本研究旨在综述牙周炎与肺炎、COPD、哮喘、COVID-19 和肺癌之间的临床关联，并提出牙周病原体在连接牙周病和肺部疾病中的可能机制和潜在作用。这可为进一步研究牙周炎与肺部疾病之间的关联提供方向，并为这两种疾病的临床诊断和治疗管理提供新的思路。
