Oddon P A, Montava M, Salburgo F, Collin M, Vercasson C, Lavieille J P
APHM, Hôpital de la Conception, Service d'Oto-rhino-laryngologie et de Chirurgie cervico-faciale, Marseille, France.
Aix Marseille Université, IFSSTAR, LBA, UMR-T 24, Marseille, France.
Acta Otorhinolaryngol Ital. 2017 Aug;37(4):320-327. doi: 10.14639/0392-100X-1094.
The aim of this study was to determine the natural history of growth and quality of life (QoL) outcomes for vestibular schwannoma (VS) managed conservatively, and to validate the disease-specific Penn Acoustic Neuroma Quality-of-Life (PANQOL) scale in French language. We retrospectively studied 26 patients with VS managed conservatively. Patient characteristics and radiological findings were collected. Two scales were used to measure QoL: the Short Form-36 Health Survey (SF-36) and the PANQOL scale translated into French. Internal consistency and scores were compared with previous studies. The mean follow-up was 25 months (range 6-72). We observed tumour growth in 14 patients (53.8%), no growth in 12 patients (46.2%) and no case of tumour shrinkage. The mean tumour growth was 2.22 mm/year. No predictive factor of growth was found. Patients with vertigo or dizziness experienced a poorer QoL according to the SF-36 (Social Functioning and Emotional Role Limitation dimensions) and to the PANQOL scale (Balance and Energy dimensions). Our results were comparable with the literature using the SF-36. With the PANQOL scale, our scores were not statistically different with those from Dutch and North American studies except in the field of hearing (p = 0.019). Quality of life becomes essential in the management of VS. According to these results, we support a non-conservative strategy associated with vestibular rehabilitation for patients with dizziness or vertigo. The PANQOL is a validated specific scale for VS, which can be useful in French.
本研究的目的是确定保守治疗的前庭神经鞘瘤(VS)的生长自然史和生活质量(QoL)结果,并验证法语版的疾病特异性宾夕法尼亚听神经瘤生活质量(PANQOL)量表。我们回顾性研究了26例接受保守治疗的VS患者。收集了患者特征和影像学检查结果。使用两个量表来测量生活质量:简明健康调查量表(SF-36)和翻译成法语的PANQOL量表。将内部一致性和得分与先前的研究进行比较。平均随访时间为25个月(范围6-72个月)。我们观察到14例患者(53.8%)肿瘤生长,12例患者(46.2%)无生长,无肿瘤缩小病例。平均肿瘤生长速度为2.22毫米/年。未发现生长的预测因素。根据SF-36(社会功能和情感角色限制维度)和PANQOL量表(平衡和能量维度),有眩晕或头晕的患者生活质量较差。我们使用SF-36的结果与文献报道相当。使用PANQOL量表时,除听力领域外(p = 0.019),我们的得分与荷兰和北美研究的得分无统计学差异。生活质量在VS的治疗中变得至关重要。根据这些结果,我们支持对有头晕或眩晕的患者采取与前庭康复相关的非保守策略。PANQOL是一种经过验证的VS特异性量表,在法语中可能有用。