Department of Infectious Diseases, Key Laboratory of Molecular Biology for Infectious Diseases, Ministry of Education, Institute for Viral Hepatitis, Centre for Lipid Research, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Adv Exp Med Biol. 2021;1316:169-189. doi: 10.1007/978-981-33-6785-2_11.
Tumors always evade immune surveillance and block T cell activation in a poorly immunogenic and immunosuppressive environment. Cancer cells and immune cells exhibit metabolic reprogramming in the tumor microenvironment (TME), which intimately links immune cell function and edits tumor immunology. In addition to glucose metabolism, amino acid and lipid metabolism also provide the materials for biological processes crucial in cancer biology and pathology. Furthermore, lipid metabolism is synergistically or negatively involved in the interactions between tumors and the microenvironment and contributes to the regulation of immune cells. Antigen processing and presentation as the initiation of adaptive immune response play a critical role in antitumor immunity. Therefore, a relationship exists between antigen-presenting cells and lipid metabolism in TME. This chapter introduces the updated understandings of lipid metabolism of tumor antigen-presenting cells and describes new directions in the manipulation of immune responses for cancer treatment.
肿瘤总是逃避免疫监视，并在免疫原性差和免疫抑制的环境中阻断 T 细胞的激活。癌细胞和免疫细胞在肿瘤微环境（TME）中表现出代谢重编程，这将免疫细胞功能与肿瘤免疫学紧密联系起来。除了葡萄糖代谢外，氨基酸和脂质代谢也为癌症生物学和病理学中至关重要的生物过程提供了物质。此外，脂质代谢协同或负向参与肿瘤与微环境的相互作用，并有助于免疫细胞的调节。抗原加工和呈递作为适应性免疫反应的启动，在抗肿瘤免疫中起着关键作用。因此，抗原呈递细胞与 TME 中的脂质代谢之间存在关系。本章介绍了肿瘤抗原呈递细胞脂质代谢的最新认识，并描述了操纵免疫反应治疗癌症的新方向。
