[来自茶褐灵芝的三萜类化合物]

[Triterpenoids from Ganoderma theaecolum].

作者信息

Liu Li-Ying, Kang Jie, Wu Chang-Hui, Li Ye, Chen Ruo-Yun

机构信息

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.

National Edible Fungi processing Technological Research Sub Center, Medicinal Fungi Cultivation and Deep Processing of National Local, Joint Engineering Research Center, Fujian Xianzhilou Biological Scienceand Technology Co., Ltd., Fuzhou 350002, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2016 Mar;41(6):1075-1080. doi: 10.4268/cjcmm20160617.

DOI:10.4268/cjcmm20160617

PMID:28875673

Abstract

Fifteenlanostane triterpenoids were isolated from the ethanol extract of Ganoderma theaecolum by means of preparative HPLC,column chromatography over silica gel,ODS and were identified as lucidone C(1),lucidone D(2),7-oxo-ganoderic acid Z2(3),7-oxo-ganoderic acid Z(4),ganoderenicacid H(5),ganoderenic acid B(6),3β,7β-dihydroyl-11,15,23-trioxo-lanost-8,16-dien-26-oic acid(7),3β,7β-dihydroyl-11,15,23-trioxo-lanost-8,16-dien-26-oic acid methyl ester(8),ganolucidic acid B(9),ganolucidate F(10),methyl ganoderate C2(11),ganoderic acid ζ(12),ganoderic acid AP3(13),methyl ganoderate B(14),and ganoderol B(15). Compounds 1-15 were isolated from this specie for the first time.

摘要

通过制备型高效液相色谱、硅胶柱色谱、ODS从茶状灵芝乙醇提取物中分离得到15种羊毛甾烷三萜类化合物，分别鉴定为灵芝酮C（1）、灵芝酮D（2）、7-氧代-灵芝酸Z2（3）、7-氧代-灵芝酸Z（4）、灵芝烯酸H（5）、灵芝烯酸B（6）、3β，7β-二羟基-11，15，23-三氧代-羊毛甾-8，16-二烯-26-酸（7）、3β，7β-二羟基-11，15，23-三氧代-羊毛甾-8，16-二烯-26-酸甲酯（8）、灵芝酸B（9）、灵芝酸F（10）、灵芝甲酯C2（11）、灵芝酸ζ（12）、灵芝酸AP3（13）、灵芝甲酯B（14）和灵芝醇B（15）。化合物1-15首次从该物种中分离得到。