代谢组学在胰岛营养感应机制中的应用。
Metabolomics applied to islet nutrient sensing mechanisms.
机构信息
Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, North Carolina.
Department of Pharmacology and Alberta Diabetes Institute, University of Alberta, Edmonton, Canada.
出版信息
Diabetes Obes Metab. 2017 Sep;19 Suppl 1(Suppl 1):90-94. doi: 10.1111/dom.13010.
Abstract
After multiple decades of investigation, the precise mechanisms involved in fuel-stimulated insulin secretion are still being revealed. One avenue for gaining deeper knowledge is to apply emergent tools of "metabolomics," involving mass spectrometry and nuclear magnetic resonance-based profiling of islet cells in their fuel-stimulated compared with basal states. The current article summarizes recent insights gained from application of metabolomics tools to the specific process of glucose-stimulated insulin secretion, revealing 2 new mechanisms that may provide targets for improving insulin secretion in diabetes.
摘要
经过几十年的研究，燃料刺激胰岛素分泌的确切机制仍在不断揭示。深入了解这一过程的一个途径是应用新兴的“代谢组学”工具，这些工具涉及对受燃料刺激和基础状态下的胰岛细胞进行质谱和基于核磁共振的分析。本文总结了代谢组学工具在葡萄糖刺激胰岛素分泌这一特定过程中的最新应用所获得的新见解，揭示了 2 种新的机制，这些机制可能为改善糖尿病中的胰岛素分泌提供靶点。
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