雌激素可减轻 SKG 关节炎模型的脊柱关节炎表现。
Estrogen attenuates the spondyloarthritis manifestations of the SKG arthritis model.
机构信息
Division of Rheumatology, Department of Internal Medicine, Soonchunhyang University Hospital, Bucheon, South Korea.
Samsung Biomedical Research Institute, Seoul, South Korea.
出版信息
Arthritis Res Ther. 2017 Sep 7;19(1):198. doi: 10.1186/s13075-017-1407-9.
BACKGROUND
Ankylosing spondylitis (AS) is a male-predominant disease, and radiographic evidence of damage is also more severe in males. Estrogen modulates immune-related processes such as T cell differentiation and cytokine production. This study aimed to evaluate the effect of estrogen on the disease activity of spondyloarthritis (SpA).
METHODS
The effects of estrogen on the development of arthritis were evaluated by performing ovariectomy and 17β-estradiol (E2) pellet implantation in zymosan-treated SKG mice. Clinical arthritis scores were measured, and F-fluorodeoxyglucose (F-FDG) small-animal positron emission tomography/computed tomography performed to quantify joint inflammation. The expression of inflammatory cytokines in joint tissue was measured.
RESULTS
E2-treated mice showed remarkable suppression of arthritis clinically and little infiltration of inflammatory cells in the Achilles tendon and intervertebral disc. F-FDG uptake was significantly lower in E2-treated mice than in sham-operated (sham) and ovariectomized mice. Expression of TNF, interferon-γ, and IL-17A was significantly reduced in E2-treated mice, whereas expression of sclerostin and Dickkopf-1 was increased in E2-treated mice compared with sham and ovariectomized mice.
CONCLUSIONS
Estrogen suppressed arthritis development in SKG mice, a model of SpA. Results of this study suggest that estrogen has an anti-inflammatory effect on the spondyloarthritis manifestations of the SKG arthritis model.
背景
强直性脊柱炎（AS）是一种男性多发疾病，且男性的放射学损伤证据也更为严重。雌激素调节免疫相关过程，如 T 细胞分化和细胞因子产生。本研究旨在评估雌激素对脊柱关节炎（SpA）疾病活动的影响。
方法
通过对酵母聚糖处理的 SKG 小鼠进行卵巢切除术和 17β-雌二醇（E2）微球植入，评估雌激素对关节炎发展的影响。测量临床关节炎评分，并进行 F-氟脱氧葡萄糖（F-FDG）小动物正电子发射断层扫描/计算机断层扫描，以定量关节炎症。测量关节组织中炎症细胞因子的表达。
结果
E2 治疗组的关节炎在临床上得到显著抑制，跟腱和椎间盘的炎症细胞浸润也很少。E2 治疗组的 F-FDG 摄取明显低于假手术（sham）和卵巢切除组。与 sham 和卵巢切除组相比，E2 治疗组 TNF、干扰素-γ 和 IL-17A 的表达明显降低，而 E2 治疗组的硬骨素和 Dickkopf-1 的表达增加。
结论
雌激素抑制了 SKG 小鼠的关节炎发展，SKG 小鼠是一种 SpA 模型。本研究结果表明，雌激素对 SKG 关节炎模型的脊柱关节炎表现具有抗炎作用。
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