加纳阿克拉科尔勒布教学医院老年内科患者中未被识别的人类免疫缺陷病毒感染及危险因素
Unrecognized human immunodeficiency virus infection and risk factors among elderly medical patients at the Korle Bu teaching hospital, Accra, Ghana.
作者信息
Adjei Andrew A, Agyemang Seth, Krampa Francis D, Abdul-Rahman Mubarak, Ofei Francis, Lartey Margaret, Adiku Theophilus K, Gyasi Richard K, Tettey Yao
机构信息
Office of Research, Innovation and Development, University of Ghana, Legon, Accra, Ghana.
Department of Pathology, School of Biomedical and Allied Health Sciences, College of Health Sciences, University of Ghana, Accra, Ghana.
出版信息
Trop Dis Travel Med Vaccines. 2016 Sep 2;2:18. doi: 10.1186/s40794-016-0034-9. eCollection 2016.
BACKGROUND
The human immunodeficiency virus (HIV) infection usually infects persons in the reproductive age group (15-49 years), but elderly people are also susceptible. Many people in sub-Saharan Africa including Ghana believe that elderly people are not at risk for HIV. Despite numerous reports of the high prevalence of HIV infection among the elderly worldwide, there are no from Ghana. This work determined the sero-prevalence of HIV infection and risk factors for its transmission among 1,100 hospitalized elderly people at the Korle Bu Teaching Hospital (KBTH), Accra, Ghana.
METHODS
Subjects voluntarily completed a risk-factor questionnaire and provided a blood specimen for HIV testing.
RESULTS
Of the study participants, 440 were male (mean age: 64 ± 10.55 years), and 660 were female (mean age: 63 ± 9.51 years). The overall HIV-1 sero-prevalence among the subjects was 4.18 % ( = 46). On multivariate analysis, there was no statistical significance between the socio-demographics or risk factors and the HIV status of the participants.
CONCLUSION
The results suggest high prevalence of HIV-1 among hospitalized elderly people at KBTH, recommending the need to include the elderly in HIV/AIDS testing, prevention, and control programmes.
TRIAL REGISTRATION
Trial registration number: MS-Et/M.9 - p4.10/2012-2013. Registered: 10th April, 2013.
背景
人类免疫缺陷病毒（HIV）感染通常发生在育龄人群（15 - 49岁）中，但老年人也易感染。包括加纳在内的撒哈拉以南非洲的许多人认为老年人没有感染HIV的风险。尽管全球有众多关于老年人中HIV感染高流行率的报道，但来自加纳的此类报道却没有。这项研究确定了加纳阿克拉科勒布教学医院（KBTH）1100名住院老年人中HIV感染的血清流行率及其传播的危险因素。
方法
研究对象自愿填写一份危险因素调查问卷，并提供血液样本进行HIV检测。
结果
在研究参与者中，440名男性（平均年龄：64 ± 10.55岁），660名女性（平均年龄：63 ± 9.51岁）。研究对象中HIV - 1的总体血清流行率为4.18%（n = 46）。多因素分析显示，社会人口统计学特征或危险因素与参与者的HIV感染状况之间无统计学意义。
结论
结果表明KBTH住院老年人中HIV - 1感染率较高，建议将老年人纳入HIV/AIDS检测、预防和控制项目。
试验注册
试验注册号：MS - Et/M.9 - p4.10/2012 - 2013。注册时间：2013年4月10日。
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