Naseri-Nosar Mahdi, Farzamfar Saeed, Sahrapeyma Hamed, Ghorbani Sadegh, Bastami Farshid, Vaez Ahmad, Salehi Majid
Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran 1417755469, Iran.
Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran 1417755469, Iran.
Mater Sci Eng C Mater Biol Appl. 2017 Dec 1;81:366-372. doi: 10.1016/j.msec.2017.08.013. Epub 2017 Aug 5.
In the present study, cerium oxide (CeO) nanoparticles were incorporated into poly (ε-caprolactone)/gelatin films in order to develop a potential wound dressing material. The wound dressings were prepared by electrospinning of poly (ε-caprolactone)/gelatin (1:1 (w/w)) solutions containing 1.50%, 3% and 6% (w/w) CeO nanoparticles. The electrospun films were evaluated regarding their morphology, contact angle, water-uptake capacity, water vapor transmission rate, tensile strength and cellular response. The film containing 1.50% CeO nanoparticles was chosen as the optimal dressing for the in vivo study on full-thickness excisional wounds of rats. The study showed that after 2weeks, the wounds treated with the CeO nanoparticle-containing dressing achieved a significant closure to nearly 100% compared with the sterile gauze with the nearly 63% of wound closure. Our results provided evidence supporting the possible applicability of CeO nanoparticle-containing wound dressing for a successful wound treatment.
在本研究中，将氧化铈（CeO）纳米颗粒掺入聚（ε-己内酯）/明胶薄膜中，以开发一种潜在的伤口敷料材料。通过静电纺丝含有1.50%、3%和6%（w/w）CeO纳米颗粒的聚（ε-己内酯）/明胶（1:1（w/w））溶液来制备伤口敷料。对静电纺丝薄膜的形态、接触角、吸水能力、水蒸气透过率、拉伸强度和细胞反应进行了评估。含有1.50%CeO纳米颗粒的薄膜被选为对大鼠全层切除伤口进行体内研究的最佳敷料。研究表明，2周后，与无菌纱布相比，用含CeO纳米颗粒的敷料治疗的伤口实现了近100%的显著愈合，而无菌纱布的伤口愈合率接近63%。我们的结果提供了证据，支持含CeO纳米颗粒的伤口敷料可能适用于成功的伤口治疗。
