百白破（DTP）疫苗。
Bordetella Adenylate Cyclase-Hemolysin Toxins.
机构信息
Institut Pasteur Unité de Prévention et Thérapies Moléculaires des Maladies Humaines, 25 rue du Dr. Roux, 75015 Paris, France.
出版信息
Toxins (Basel). 2017 Sep 11;9(9):277. doi: 10.3390/toxins9090277.
Abstract
Adenylate cyclase-hemolysin toxin is secreted and produced by three classical species of the genus : , and . This toxin has several properties such as: (i) adenylate cyclase activity, enhanced after interaction with the eukaryotic protein, calmodulin; (ii) a pore-forming activity; (iii) an invasive activity. It plays an important role in the pathogenesis of these species responsible for whooping cough in humans or persistent respiratory infections in mammals, by modulating host immune responses. In contrast with other toxins or adhesins, lack of (or very low polymorphism) is observed in the structural gene encoding this toxin, supporting its importance as well as a potential role as a vaccine antigen against whooping cough. In this article, an overview of the investigations undertaken on this toxin is presented.
摘要
腺苷酸环化酶-溶血素毒素由三个经典的属种分泌和产生： 、 和 。这种毒素具有多种特性，如：（i）腺苷酸环化酶活性，与真核蛋白钙调蛋白相互作用后增强；（ii）形成孔的活性；（iii）侵袭活性。它在这些种的发病机制中起着重要作用，这些种导致人类百日咳或哺乳动物持续呼吸道感染，通过调节宿主免疫反应。与其他毒素或黏附素不同，在编码这种毒素的结构基因中观察到缺乏（或非常低的多态性），这支持了它的重要性以及作为百日咳疫苗抗原的潜在作用。本文对该毒素的研究进行了综述。
相似文献
1
Bordetella Adenylate Cyclase-Hemolysin Toxins.
Toxins (Basel). 2017 Sep 11;9(9):277. doi: 10.3390/toxins9090277.
2
Characterization of Post-Translational Modifications and Cytotoxic Properties of the Adenylate-Cyclase Hemolysin Produced by Various Bordetella pertussis and Bordetella parapertussis Isolates.
Toxins (Basel). 2017 Sep 26;9(10):304. doi: 10.3390/toxins9100304.
3
The Eukaryotic Host Factor 14-3-3 Inactivates Adenylate Cyclase Toxins of Bordetella bronchiseptica and B. parapertussis, but Not B. pertussis.
mBio. 2018 Aug 28;9(4):e00628-18. doi: 10.1128/mBio.00628-18.
4
filamentous hemagglutinin and adenylate cyclase toxin interactions on the bacterial surface are consistent with FhaB-mediated delivery of ACT to phagocytic cells.
mBio. 2024 May 8;15(5):e0063224. doi: 10.1128/mbio.00632-24. Epub 2024 Mar 27.
5
Role of Major Toxin Virulence Factors in Pertussis Infection and Disease Pathogenesis.
Adv Exp Med Biol. 2019;1183:35-51. doi: 10.1007/5584_2019_403.
6
Molecular aspects of Bordetella pertussis pathogenesis.
Int Microbiol. 1999 Sep;2(3):137-44.
7
Cyclic AMP-Elevating Capacity of Adenylate Cyclase Toxin-Hemolysin Is Sufficient for Lung Infection but Not for Full Virulence of Bordetella pertussis.
Infect Immun. 2017 May 23;85(6). doi: 10.1128/IAI.00937-16. Print 2017 Jun.
8
Bordetella adenylate cyclase is a virulence associated factor and an immunoprotective antigen.
Microb Pathog. 1989 Nov;7(5):373-80. doi: 10.1016/0882-4010(89)90040-5.
9
Selective Enhancement of the Cell-Permeabilizing Activity of Adenylate Cyclase Toxin Does Not Increase Virulence of .
Int J Mol Sci. 2021 Oct 28;22(21):11655. doi: 10.3390/ijms222111655.
10
Bordetella pertussis Adenylate Cyclase Toxin Disrupts Functional Integrity of Bronchial Epithelial Layers.
Infect Immun. 2018 Feb 20;86(3). doi: 10.1128/IAI.00445-17. Print 2018 Mar.
引用本文的文献
1
Pertussis resurgence: epidemiological trends, pathogenic mechanisms, and preventive strategies.
Front Immunol. 2025 Jul 10;16:1618883. doi: 10.3389/fimmu.2025.1618883. eCollection 2025.
2
CyaA translocation across eukaryotic cell membranes.
Front Mol Biosci. 2024 Mar 22;11:1359408. doi: 10.3389/fmolb.2024.1359408. eCollection 2024.
3
and : Similarities and Differences in Infection, Immuno-Modulation, and Vaccine Considerations.
Clin Microbiol Rev. 2023 Sep 21;36(3):e0016422. doi: 10.1128/cmr.00164-22. Epub 2023 Jun 12.
4
A Robust and Sensitive Spectrophotometric Assay for the Enzymatic Activity of Bacterial Adenylate Cyclase Toxins.
Toxins (Basel). 2022 Oct 8;14(10):691. doi: 10.3390/toxins14100691.
5
Design of a Quantitative LC-MS Method for Residual Toxins Adenylate Cyclase Toxin (ACT), Dermonecrotic Toxin (DNT) and Tracheal Cytotoxin (TCT) in Vaccines.
Toxins (Basel). 2021 Oct 28;13(11):763. doi: 10.3390/toxins13110763.
6
Pathogenicity and virulence of and its adaptation to its strictly human host.
Virulence. 2021 Dec;12(1):2608-2632. doi: 10.1080/21505594.2021.1980987.
7
Isolation, Antimicrobial Resistance Phenotypes, and Virulence Genes of From Pigs in China, 2018-2020.
Front Vet Sci. 2021 Jun 8;8:672716. doi: 10.3389/fvets.2021.672716. eCollection 2021.
8
Almost half of the RTX domain is dispensable for complement receptor 3 binding and cell-invasive activity of the Bordetella adenylate cyclase toxin.
J Biol Chem. 2021 Jul;297(1):100833. doi: 10.1016/j.jbc.2021.100833. Epub 2021 May 26.
9
A High-Affinity Calmodulin-Binding Site in the CyaA Toxin Translocation Domain is Essential for Invasion of Eukaryotic Cells.
Adv Sci (Weinh). 2021 Mar 8;8(9):2003630. doi: 10.1002/advs.202003630. eCollection 2021 May.
10
Bioengineering of Adenylate Cyclase Toxin for Vaccine Development and Other Biotechnological Purposes.
Toxins (Basel). 2021 Jan 22;13(2):83. doi: 10.3390/toxins13020083.
本文引用的文献
1
Characterization of Post-Translational Modifications and Cytotoxic Properties of the Adenylate-Cyclase Hemolysin Produced by Various Bordetella pertussis and Bordetella parapertussis Isolates.
Toxins (Basel). 2017 Sep 26;9(10):304. doi: 10.3390/toxins9100304.
2
Bordetella parapertussis outbreak in Southeastern Minnesota and the United States, 2014.
Medicine (Baltimore). 2017 May;96(20):e6730. doi: 10.1097/MD.0000000000006730.
3
Cyclic AMP-Elevating Capacity of Adenylate Cyclase Toxin-Hemolysin Is Sufficient for Lung Infection but Not for Full Virulence of Bordetella pertussis.
Infect Immun. 2017 May 23;85(6). doi: 10.1128/IAI.00937-16. Print 2017 Jun.
4
Stability, structural and functional properties of a monomeric, calcium-loaded adenylate cyclase toxin, CyaA, from Bordetella pertussis.
Sci Rep. 2017 Feb 10;7:42065. doi: 10.1038/srep42065.
5
Fine Epitope Mapping of Two Antibodies Neutralizing the Bordetella Adenylate Cyclase Toxin.
Biochemistry. 2017 Mar 7;56(9):1324-1336. doi: 10.1021/acs.biochem.6b01163. Epub 2017 Feb 23.
6
Outer membrane vesicles: an attractive candidate for pertussis vaccines.
Expert Rev Vaccines. 2017 Mar;16(3):193-196. doi: 10.1080/14760584.2017.1276832. Epub 2016 Dec 30.
7
Bordetella pertussis outer membrane vesicle vaccine confers equal efficacy in mice with milder inflammatory responses compared to a whole-cell vaccine.
Sci Rep. 2016 Dec 1;6:38240. doi: 10.1038/srep38240.
8
Modulation of Pertussis and Adenylate Cyclase Toxins by Sigma Factor RpoE in Bordetella pertussis.
Infect Immun. 2016 Dec 29;85(1). doi: 10.1128/IAI.00565-16. Print 2017 Jan.
9
Use of a Toxin Neutralization Assay To Characterize the Serologic Response to Adenylate Cyclase Toxin after Infection with Bordetella pertussis.
Clin Vaccine Immunol. 2017 Jan 5;24(1). doi: 10.1128/CVI.00370-16. Print 2017 Jan.
10
Bordetella adenylate cyclase toxin interacts with filamentous haemagglutinin to inhibit biofilm formation in vitro.
Mol Microbiol. 2017 Jan;103(2):214-228. doi: 10.1111/mmi.13551. Epub 2016 Nov 3.
Zotero 插件