Institut Pasteur Unité de Prévention et Thérapies Moléculaires des Maladies Humaines, 25 rue du Dr. Roux, 75015 Paris, France.
Toxins (Basel). 2017 Sep 11;9(9):277. doi: 10.3390/toxins9090277.
Adenylate cyclase-hemolysin toxin is secreted and produced by three classical species of the genus : , and . This toxin has several properties such as: (i) adenylate cyclase activity, enhanced after interaction with the eukaryotic protein, calmodulin; (ii) a pore-forming activity; (iii) an invasive activity. It plays an important role in the pathogenesis of these species responsible for whooping cough in humans or persistent respiratory infections in mammals, by modulating host immune responses. In contrast with other toxins or adhesins, lack of (or very low polymorphism) is observed in the structural gene encoding this toxin, supporting its importance as well as a potential role as a vaccine antigen against whooping cough. In this article, an overview of the investigations undertaken on this toxin is presented.
腺苷酸环化酶-溶血素毒素由三个经典的属种分泌和产生： 、 和 。这种毒素具有多种特性，如：（i）腺苷酸环化酶活性，与真核蛋白钙调蛋白相互作用后增强；（ii）形成孔的活性；（iii）侵袭活性。它在这些种的发病机制中起着重要作用，这些种导致人类百日咳或哺乳动物持续呼吸道感染，通过调节宿主免疫反应。与其他毒素或黏附素不同，在编码这种毒素的结构基因中观察到缺乏（或非常低的多态性），这支持了它的重要性以及作为百日咳疫苗抗原的潜在作用。本文对该毒素的研究进行了综述。
