Department of Medicine, Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Experimental, Diagnostic, Specialty Medicine, Nephrology, Dialysis, and Renal Transplant Unit, S. Orsola University Hospital, Bologna, Italy.
Transpl Int. 2017 Dec;30(12):1199-1208. doi: 10.1111/tri.13068. Epub 2017 Oct 5.
Regenerative medicine promises to meet two of the most urgent needs of modern organ transplantation, namely immunosuppression-free transplantation and an inexhaustible source of organs. Ideally, bioengineered organs would be manufactured from a patient's own biomaterials-both cells and the supporting scaffolding materials in which cells would be embedded and allowed to mature to eventually regenerate the organ in question. While some groups are focusing on the feasibility of this approach, few are focusing on the immunogenicity of the scaffolds that are being developed for organ bioengineering purposes. This review will succinctly discuss progress in the understanding of immunological characteristics and behavior of different scaffolds currently under development, with emphasis on the extracellular matrix scaffolds obtained decellularized animal or human organs which seem to provide the ideal template for bioengineering purposes.
再生医学有望满足现代器官移植最紧迫的两个需求，即无免疫抑制的移植和源源不断的器官来源。理想情况下，生物工程器官将由患者自身的生物材料制造而成，包括细胞和支持细胞嵌入并成熟以最终再生目标器官的支架材料。虽然有些研究小组专注于这种方法的可行性，但很少有研究小组关注为器官生物工程目的开发的支架的免疫原性。这篇综述将简洁地讨论目前正在开发的不同支架的免疫特性和行为的理解进展，重点是从动物或人器官脱细胞获得的细胞外基质支架，它们似乎为生物工程目的提供了理想的模板。
