Lohi Hima S, Nayak Dilip G, Uppoor Ashita S
Senior Lecturer, Department of Periodontics, PSM College of Dental Science and Research, Thrissur, Kerala, India.
Dean, Department of Periodontics, Manipal College of Dental Sciences, Manipal University, Mangaluru, Karnataka, India.
J Clin Diagn Res. 2017 Jul;11(7):ZC76-ZC80. doi: 10.7860/JCDR/2017/23113.10255. Epub 2017 Jul 1.
Predictable closure of furcation defects with bone grafts, Guided Tissue Regeneration (GTR) and a combination of the two has remained an elusive goal so far. Hence, evaluation of biomimetic agents as candidate technologies for periodontal regeneration merit due consideration. In this study, Choukroun's Platelet Rich Fibrin (PRF), a second generation platelet concentrate, is combined with bone graft to examine if the addition enhances the therapeutic potential of bone graft in the management of Class II furcation defects.
To evaluate and compare the clinical effectiveness of Bioactive Ceramic Composite Granules (BCCG) alone and in combination with PRF in the treatment of mandibular Class II furcation defects.
Twenty mandibular Class II furcation defects in 16 systemically healthy patients were randomly allocated to test and control groups. Test sites were treated with PRF and bone graft, while control sites were treated with BCCG alone. Soft tissue parameters (probing pocket depth and clinical attachment loss), hard tissue parameters (vertical and horizontal depth of furcation defects) and radiographic parameter (radiographic alveolar bone density) were measured at baseline and six months post surgery. Statistical analysis was performed using Wilcoxon signed rank test for intragroup comparison of parameters and Mann-Whitney U test for intergroup comparison.
Statistically significant improvement was observed in the test group compared to the control group with respect to all the measured parameters. However, complete furcation closure was not observed at any of the treated sites.
Adjunctive use of PRF with bone graft may be a more effective treatment modality in the management of mandibular Class II furcation defects when compared to bone graft alone.
迄今为止，通过骨移植、引导组织再生（GTR）以及两者结合来可预测地关闭根分叉病变仍是一个难以实现的目标。因此，将仿生制剂作为牙周再生的候选技术进行评估值得充分考虑。在本研究中，第二代血小板浓缩物——舒可复富血小板纤维蛋白（PRF）与骨移植相结合，以检验这种添加是否能增强骨移植在下颌Ⅱ度根分叉病变治疗中的治疗潜力。
评估并比较生物活性陶瓷复合颗粒（BCCG）单独使用以及与PRF联合使用治疗下颌Ⅱ度根分叉病变的临床效果。
将16例全身健康患者的20个下颌Ⅱ度根分叉病变随机分为试验组和对照组。试验组采用PRF和骨移植治疗，而对照组仅采用BCCG治疗。在基线和术后6个月测量软组织参数（探诊深度和临床附着丧失）、硬组织参数（根分叉病变的垂直和水平深度）以及影像学参数（牙槽骨密度）。采用Wilcoxon符号秩检验进行组内参数比较，采用Mann-Whitney U检验进行组间比较。
与对照组相比，试验组在所有测量参数方面均观察到具有统计学意义的改善。然而，在任何治疗部位均未观察到根分叉完全关闭。
与单独使用骨移植相比，PRF与骨移植联合使用可能是治疗下颌Ⅱ度根分叉病变更有效的治疗方式。
