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植物和草药衍生药物在心脏病治疗中的应用。

Use of Plant and Herb Derived Medicine for Therapeutic Usage in Cardiology.

作者信息

Koo Ye Eun, Song Jiwon, Bae Soochan

机构信息

Beth Israel Deaconess Medical Center, Cardiovascular Institute, 3 Blackfan Circle, CLS 910, Boston, MA 02215, USA.

出版信息

Medicines (Basel). 2018 Apr 22;5(2):38. doi: 10.3390/medicines5020038.

Abstract

Cardiovascular diseases (CVDs) have become prominent in mortality and morbidity rates. Prevalent cardiovascular conditions, such as hypertension, atherosclerosis and oxidative stress, are increasing at an alarming rate. Conventional drugs have been associated with adverse effects, suggesting a need for an alternative measure to ameliorate CVD. A number of plant- and herb-derived preventative food and therapeutic drugs for cardiovascular conditions are progressively used for their various benefits. Naturally derived food and drugs have fewer side effects because they come from natural elements; preventative food, such as grape seed, inhibits changes of histopathology and biomarkers in vital organs whereas therapeutic drugs, for instance Xanthone, improve heart functions by suppressing oxidative stress of myocyte. This review closely examines the various plant- and herb-derived drugs that have assumed an essential role in treating inflammation and oxidative stress for prevalent cardiovascular conditions. Furthermore, the use of plant-derived medicine with other synthetic particles, such as nanoparticles, for targeted therapy is investigated for its effective clinical use in the future.

摘要

心血管疾病(CVDs)在死亡率和发病率方面已变得十分突出。常见的心血管疾病,如高血压、动脉粥样硬化和氧化应激,正以惊人的速度增加。传统药物已被证实存在不良反应,这表明需要一种替代措施来改善心血管疾病。许多源自植物和草药的预防性食品及治疗药物因其多种益处而逐渐被用于心血管疾病的治疗。天然来源的食品和药物副作用较少,因为它们来自天然成分;预防性食品,如葡萄籽,可抑制重要器官组织病理学和生物标志物的变化,而治疗药物,如呫吨酮,则通过抑制心肌细胞的氧化应激来改善心脏功能。本综述密切研究了各种源自植物和草药的药物,这些药物在治疗常见心血管疾病的炎症和氧化应激方面发挥了重要作用。此外,还探讨了将植物源药物与其他合成颗粒(如纳米颗粒)结合用于靶向治疗,以期其在未来能有有效的临床应用。

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