Botman M J, de Krieger R A
Department of Infection Control, de Stadsmaten General Hospital, Enschede, The Netherlands.
J Hosp Infect. 1987 Sep;10(2):204-8. doi: 10.1016/0195-6701(87)90148-4.
The effect of the use of small-volume medication nebulizers on oropharyngeal colonization with potentially pathogenic Gram-negative bacilli was investigated in 95 patients with respiratory disease, of whom 54 used nebulizers and 41 were controls. Inhalation therapy had a significant effect on colonization, with a relative risk of more than four. Age over 60 years also showed a significant association with colonization. One-third of the nebulizers sampled were contaminated, 71% with Gram-negative bacilli. A direct route of contamination could be demonstrated in 28% of the patients. Medication nebulizers should be thoroughly cleaned after use and stored dry between patients.
对95例呼吸系统疾病患者进行了研究，以探讨使用小容量药物雾化器对口咽部潜在致病性革兰氏阴性杆菌定植的影响，其中54例使用雾化器，41例为对照组。吸入疗法对定植有显著影响，相对风险超过4倍。60岁以上的年龄也与定植有显著关联。所采集的雾化器中有三分之一被污染，71%被革兰氏阴性杆菌污染。在28%的患者中可证实存在直接污染途径。药物雾化器使用后应彻底清洁，并在患者之间干燥保存。
