Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada; Terrence Donnelly Centre for Cellular and Bimolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada; Centre for Global Engineering, University of Toronto, Toronto, Ontario M5S 1A4, Canada.
Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada; Terrence Donnelly Centre for Cellular and Bimolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada; Botany and Microbiology Department, Faculty of Science, Zagazig University, Egypt.
Biomaterials. 2017 Nov;146:97-114. doi: 10.1016/j.biomaterials.2017.08.013. Epub 2017 Aug 17.
Infectious diseases are a major global threat that accounts for one of the leading causes of global mortality and morbidity. Prompt diagnosis is a crucial first step in the management of infectious threats, which aims to quarantine infected patients to avoid contacts with healthy individuals and deliver effective treatments prior to further spread of diseases. This review article discusses current advances of diagnostic systems using colloidal nanomaterials (e.g., gold nanoparticles, quantum dots, magnetic nanoparticles) for identifying and differentiating infectious pathogens. The challenges involved in the clinical translation of these emerging nanotechnology based diagnostic devices will also be discussed.
传染病是全球主要威胁之一,也是导致全球死亡率和发病率的主要原因之一。及时诊断是管理传染病威胁的关键第一步,其目的是隔离感染患者,避免与健康个体接触,并在疾病进一步传播之前提供有效的治疗。本文综述了利用胶体纳米材料(例如金纳米颗粒、量子点、磁性纳米颗粒)鉴定和区分感染性病原体的诊断系统的最新进展。本文还讨论了这些新兴纳米技术诊断设备在临床转化中所面临的挑战。