Hu Jianqiang, Wang Zhouping, Li Jinghong
Department of Chemistry, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, Beijing 100084, China.
Sensors (Basel). 2007 Dec 14;7(12):3299-3311. doi: 10.3390/s7123299.
Specially shaped gold nanoparticles have intrigued considerable attention becausethey usually possess high-sensitivity surface-enhanced Raman scattering (SERS) and thusresult in large advantages in trace biodetermination. In this article, starch-capped goldnanoparticles with hexagon and boot shapes were prepared through using a nontoxic andbiologically benign aqueous-phase synthetic route. Shape effects of gold nanoparticles onSERS properties were mainly investigated, and found that different-shaped goldnanoparticles possess different SERS properties. Especially, the boot-shaped nanoparticlescould induce more 100-fold SERS enhancements in sensitivity as compared with those fromgold nanospheres. The extremely strong SERS properties of gold nanoboots have beensuccessfully applied to the detection of avidin. The unique nanoboots with high-sensitivitySERS properties are also expected to find use in many other fields such as biolabel,bioassay, biodiagnosis, and even clinical diagnosis and therapy.
特殊形状的金纳米粒子引起了广泛关注，因为它们通常具有高灵敏度的表面增强拉曼散射（SERS），因此在痕量生物测定中具有很大优势。在本文中，通过使用无毒且生物良性的水相合成路线制备了具有六边形和靴子形状的淀粉包覆金纳米粒子。主要研究了金纳米粒子的形状对SERS性能的影响，发现不同形状的金纳米粒子具有不同的SERS性能。特别是，与金纳米球相比，靴子形状的纳米粒子在灵敏度上可诱导超过100倍的SERS增强。金纳米靴极强的SERS性能已成功应用于抗生物素蛋白的检测。具有高灵敏度SERS性能的独特纳米靴也有望在许多其他领域得到应用，如生物标记、生物测定、生物诊断，甚至临床诊断和治疗。
