Souza Natália Cabral, de Oliveira Juliana Medeiros, Morrone Maurílio da Silva, Albanus Ricardo D'Oliveira, Amarante Maria do Socorro Medeiros, Camillo Christina da Silva, Langassner Silvana Maria Zucolotto, Gelain Daniel Pens, Moreira José Cláudio Fonseca, Dalmolin Rodrigo Juliani Siqueira, Pasquali Matheus Augusto de Bittencourt
Institute of Tropical Medicine of Rio Grande do Norte, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
Department of Biochemistry, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
Evid Based Complement Alternat Med. 2017;2017:2787308. doi: 10.1155/2017/2787308. Epub 2017 Aug 17.
In tropical America, principally in Northeastern Brazil, the leaf extract of is traditionally used for treatment of different diseases. However, chemical and biological properties and activities of are poorly investigated and known. Here, we evaluated the antioxidant and anti-inflammatory activities of leaf extract from Our results show that leaf extract exhibits antioxidant activity when used to treat RAW 264.7 macrophage cells. Antioxidant effects were observed by decrease in oxidative damage in macrophage cells treated with 0.5 g/mL and 5 g/mL of leaf extract. Moreover, leaf extract reversed oxidative damage and inflammatory parameters induced in LPS-stimulated RAW 264.7 macrophage cells. Leaf extract at 0.5 g/mL and 5 g/mL was able to inhibit release of TNF- and IL-1 in LPS-stimulated cells. Taken together, our results indicate antioxidant and anti-inflammatory effects of leaf extract from and reveal the positive effects that intake of these products can mediate in biological system.
在热带美洲，主要是巴西东北部，[植物名称]的叶提取物传统上用于治疗各种疾病。然而，[植物名称]的化学和生物学特性及活性研究甚少且鲜为人知。在此，我们评估了[植物名称]叶提取物的抗氧化和抗炎活性。我们的结果表明，叶提取物用于处理RAW 264.7巨噬细胞时具有抗氧化活性。在用0.5 g/mL和5 g/mL叶提取物处理的巨噬细胞中，通过氧化损伤的减少观察到了抗氧化作用。此外，叶提取物逆转了LPS刺激的RAW 264.7巨噬细胞中诱导的氧化损伤和炎症参数。0.5 g/mL和5 g/mL的叶提取物能够抑制LPS刺激细胞中TNF-和IL-1的释放。综上所述，我们的结果表明[植物名称]叶提取物具有抗氧化和抗炎作用，并揭示了摄入这些产品在生物系统中可介导的积极作用。
