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使用聚氨基磺酸修饰玻碳电极伏安法测定药品中的绿原酸。

Voltammetric determination of chlorogenic acid in pharmaceutical products using poly(aminosulfonic acid) modified glassy carbon electrode.

作者信息

Chao Mingyong, Ma Xinying

机构信息

Department of Chemistry and Chemical Engineering, Heze University, Heze 274015, PR China.

Department of Chemistry and Chemical Engineering, Heze University, Heze 274015, PR China.

出版信息

J Food Drug Anal. 2014 Dec;22(4):512-519. doi: 10.1016/j.jfda.2013.12.006. Epub 2014 Mar 18.

DOI:10.1016/j.jfda.2013.12.006
PMID:28911468
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9355007/
Abstract

In this work, a poly(aminosulfonic acid) modified glassy carbon electrode was fabricated and the electrochemical behavior of chlorogenic acid (CGA) was studied by cyclic voltammetry. Compared with a bare glassy carbon electrode, the modified electrode exhibits excellent catalytic effect on the electrochemical redox of CGA. Utilizing this catalytic effect, a sensitive and selective electrochemical method for the determination of CGA was developed. The analytical parameters were optimized. Under the optimized conditions, the oxidation peak current is linearly proportional to the concentration of CGA in the range from 4.00 × 10 to 1.20 × 10 mol/L and the detection limit is 4.00 × 10 mol/L. Further, the performance of the proposed method has been validated in terms of linearity (r = 0.9995), recovery (96.3-102.8%), reproducibility (RSD ＜ 4.0%, n = 6) and robustness. The developed method has been successfully applied for the determination of CGA in a variety of pharmaceutical products.

摘要

在本工作中，制备了一种聚氨基磺酸修饰的玻碳电极，并采用循环伏安法研究了绿原酸（CGA）的电化学行为。与裸玻碳电极相比，修饰电极对CGA的电化学氧化还原表现出优异的催化作用。利用这种催化作用，建立了一种灵敏且选择性好的测定CGA的电化学方法。对分析参数进行了优化。在优化条件下，氧化峰电流与CGA浓度在4.00×10至1.20×10 mol/L范围内呈线性关系，检测限为4.00×10 mol/L。此外，该方法的线性（r = 0.9995）、回收率（96.3 - 102.8%）、重现性（RSD ＜ 4.0%，n = 6）和稳健性均得到了验证。所建立的方法已成功应用于多种药品中CGA的测定。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ceb/9355007/5abae24a6436/jfda-22-04-512f9.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ceb/9355007/5abae24a6436/jfda-22-04-512f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ceb/9355007/23955f91e9be/jfda-22-04-512f1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ceb/9355007/46a7419c581c/jfda-22-04-512f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ceb/9355007/b70e3ad9e3af/jfda-22-04-512f6.jpg
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