Childs J E, Glass G E, Korch G W, LeDuc J W
Department of Immunology and Infectious Diseases, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205.
Am J Trop Med Hyg. 1987 Nov;37(3):648-62. doi: 10.4269/ajtmh.1987.37.648.
We used a prospective seroepidemiological study, in conjunction with a mark-release-recapture protocol, to investigate the transmission of hantaviruses in four rodent species from Baltimore, Maryland, from June 1984 to June 1986. A total of 1,208 captures of 762 rodents provided 984 individual blood samples. The antibody prevalence, as determined by frequency of reciprocal indirect fluorescent antibody (IFA) titers greater than or equal to 32, was 33.9% in rats (Rattus norvegicus, n = 466), 28.3% in meadow voles (Microtus pennsylvanicus, n = 67), 1.4% in house mice (Mus musculus, n = 146), and 1.2% in white-footed mice (Peromyscus leucopus, n = 83). Populations of all rodents were maximal during the fall and winter months, but population trends were not clearly associated with periods of virus transmission. The mean incidence of seroconversion to a Hantavirus for rats was 12.06/100 rats/month, but incidence rates could not be established for other species. Rats which seroconverted were generally sexually mature animals, and there was evidence of transmission throughout the year. Animals which seroconverted to a Hantavirus achieved high IFA titers, and remained seropositive for the duration of the study.
1984年6月至1986年6月，我们采用前瞻性血清流行病学研究，并结合标记重捕法，调查了马里兰州巴尔的摩市四种啮齿动物中汉坦病毒的传播情况。总共捕获了762只啮齿动物，共1208次，提供了984份个体血样。通过双向间接荧光抗体（IFA）效价大于或等于32的频率确定的抗体阳性率，在大鼠（褐家鼠，n = 466）中为33.9%，在田鼠（宾夕法尼亚田鼠，n = 67）中为28.3%，在小家鼠（小家鼠，n = 146）中为1.4%，在白足鼠（白足鼠，n = 83）中为1.2%。所有啮齿动物的种群数量在秋季和冬季达到最大值，但种群趋势与病毒传播时期没有明显关联。大鼠血清转化为汉坦病毒的平均发病率为12.06/100只大鼠/月，但其他物种的发病率无法确定。血清转化的大鼠通常是性成熟动物，并且有全年传播的证据。血清转化为汉坦病毒的动物获得了高IFA效价，并在研究期间保持血清阳性。
