汉坦病毒肺综合征与白足鼠（白足鼠属）的分子关联：纽约病毒M基因组的遗传特征分析
Molecular linkage of hantavirus pulmonary syndrome to the white-footed mouse, Peromyscus leucopus: genetic characterization of the M genome of New York virus.
作者信息
Hjelle B, Lee S W, Song W, Torrez-Martinez N, Song J W, Yanagihara R, Gavrilovskaya I, Mackow E R
机构信息
Department of Pathology, University of New Mexico Health Science Center, Albuquerque, USA.
出版信息
J Virol. 1995 Dec;69(12):8137-41. doi: 10.1128/JVI.69.12.8137-8141.1995.
Abstract
The complete M segment sequences of hantaviruses amplified from tissues of a patient with hantavirus pulmonary syndrome in the northeastern United States and from white-footed mice, Peromyscus leucopus, from New York were 99% identical and differed from those of Four Corners virus by 23%. The serum of this patient failed to recognize a conserved, immunodominant epitope of the Four Corners virus G1 glycoprotein. Collectively, these findings indicate that P. leucopus harbors a genetically and antigenically distinct hantavirus that causes hantavirus pulmonary syndrome.
摘要
从美国东北部一名汉坦病毒肺综合征患者的组织以及来自纽约的白足鼠（白足鼠属）中扩增出的汉坦病毒M片段完整序列，有99%的同一性，与四角病毒的序列相差23%。该患者的血清未能识别四角病毒G1糖蛋白的一个保守的、免疫显性表位。总的来说，这些发现表明白足鼠携带一种在基因和抗原性上都不同的汉坦病毒，该病毒可导致汉坦病毒肺综合征。
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