Kawamura K, Zhang X K, Arikawa J, Takashima I, Dempo K, Hashimoto N
Department of Veterinary Public Health, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Acta Virol. 1991 Jan;35(1):54-63.
Adult Wistar rats (Rattus norvegicus), Apodemus agrarius, Meriones unguiculatus, Clethrionomys rufocanus, and Apodemus argenteus were inoculated with Rattus-type (SR-11, KI-262, and TB-314) or Apodemus-type (Hantaan 76-118) hantaviruses. Production of serum antibody to the inoculated virus (IAHA titres of 1:32 to 1:4 096) was obsersved in all rodent species 10 weeks after virus inoculation. Rattus-type virus was detected in some organs of all the rodent species employed except of Apodemus agrarius. Apodemus-type virus was found only in some organs of Apodemus agrarius. Newborn Wistar rats induced antibody in high titres to both Rattus- and Apodemus-type hantaviruses. Rattus-type virus was detected in all the organs examined for up to 6 weeks after inoculation, whereas Apodemus-type virus disappeared from all organs except of brain and lung tissues. The virulence of the three Rattus-type viruses to newborn rats was different. These findings indicate that the susceptibility of rodents may vary depending on the combination of rodent species and virus strains; they also suggest that the various species of rodents may be the reservoir animals of hantavirus infection in nature.
将成年Wistar大鼠（褐家鼠）、黑线姬鼠、长爪沙鼠、棕背䶄和小林姬鼠接种大鼠型（SR - 11、KI - 262和TB - 314）或姬鼠型（汉滩76 - 118）汉坦病毒。在病毒接种10周后，在所有啮齿动物物种中均观察到针对接种病毒的血清抗体产生（间接免疫荧光抗体试验效价为1:32至1:4096）。在所使用的所有啮齿动物物种的某些器官中检测到大鼠型病毒，但黑线姬鼠除外。仅在黑线姬鼠的某些器官中发现姬鼠型病毒。新生Wistar大鼠对大鼠型和姬鼠型汉坦病毒均产生高滴度抗体。接种后长达6周，在所有检测的器官中均检测到大鼠型病毒，而姬鼠型病毒除脑和肺组织外从所有器官中消失。三种大鼠型病毒对新生大鼠的毒力不同。这些发现表明，啮齿动物的易感性可能因啮齿动物物种和病毒株的组合而异；它们还表明，自然界中各种啮齿动物物种可能是汉坦病毒感染的储存宿主动物。
