Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY 13699-5810, USA.
Applied Organic Chemistry Department, National Research Centre (NRC), El Bohouth st., Dokki, 12622-Giza, Egypt.
Sensors (Basel). 2017 Sep 15;17(9):2121. doi: 10.3390/s17092121.
Nanomaterial-based sensing approaches that incorporate different types of nanoparticles (NPs) and nanostructures in conjunction with natural or synthetic receptors as molecular recognition elements provide opportunities for the design of sensitive and selective assays for rapid detection of contaminants. This review summarizes recent advancements over the past ten years in the development of nanotechnology-enabled sensors and systems for capture and detection of pathogens. The most common types of nanostructures and NPs, their modification with receptor molecules and integration to produce viable sensing systems with biorecognition, amplification and signal readout are discussed. Examples of all-in-one systems that combine multifunctional properties for capture, separation, inactivation and detection are also provided. Current trends in the development of low-cost instrumentation for rapid assessment of food contamination are discussed as well as challenges for practical implementation and directions for future research.
基于纳米材料的传感方法，将不同类型的纳米粒子（NPs）和纳米结构与天然或合成受体结合作为分子识别元件，为快速检测污染物的灵敏和选择性分析提供了机会。本综述总结了过去十年中在开发用于捕获和检测病原体的纳米技术传感器和系统方面的最新进展。讨论了最常见的纳米结构和 NPs 类型、它们与受体分子的修饰以及整合以产生具有生物识别、放大和信号读出功能的可行传感系统。还提供了用于捕获、分离、失活和检测的多功能一体化系统的实例。还讨论了用于快速评估食品污染的低成本仪器的发展趋势以及实际实施的挑战和未来研究的方向。
